Objective：The study aims to provide new targets for the prevention and treatment of newly diagnosed T2DM with HUA by analyzing the clinical features and the gut microbiome.Methods：A total of 103 patients with newly diagnosed T2DM and 98 patients with T2DM with HUA were included. According to the admission conditions，agE- and gender⁃matched newly diagnosed T2DM patients with HUA(DMUA group) and newly diagnosed T2DM patients(T2DM group) were selected，and age ⁃ and gender ⁃ matched hyperuricemia patients(HUA group)and healthy volunteers(Control group)were included at the same time. The clinical data and biochemical test results were recorded. The data were analyzed by chi⁃square test，analysis of variance，Tukey⁃HSD Test and Wilcoxon rank sum test method. Stool samples of 4 groups were collected and sequenced by 16S rRNA high⁃throughput sequencing method and all the data were finally analyzed by bioinformatics. Results：①Comparison of clinical features：CHO，TG，AI were higher in DMUA than T2DM group，LDL in DMUA was only higher than the T2DM group with a history of more than 5 years. DMUA group were youngerand had a greater prevalence of fatty liver than T2DM group，but HbA1c in DMUA was lower than T2DM group. Compared with the T2DM group，HUA group and the Control group，the DMUA group had a significant decrease in high ⁃ density lipoprotein and a significant increase in triglycerides. And compared with the T2DM group and HUA group，the arteriosclerosis index of DMUA groups was significantly increased.②The gut microbiome analysis：The α diversity index of the DMUA group was significantly lower than that of the Control group. There was a significant difference in β diversity between the DMUA group，Control group and the HUA group. In the analysis of bacteria abundance，compared with the HUA group，f_Prevotellaceae and g_Megamonas were significantly increased in the DMUA group，while p_Bacteroidetes，c_Bacteroidia，o_Bacteroidales，f_Bacteroidaceae，g_Bacteroides，f_Tannerellaceae and g_Parabacteroides were significantly decreased. Compared with the Control group， c_clostridia， o_clostridiales， f_Peptostreptococcaceae and g_Romboutsia were significantly decreased in the DMUA group. Conclusion：Compared with long⁃course T2DM with HUA and newly diagnosed T2DM alone，the group with newly diagnosed T2DM with HUA is more likely to have abnormal lipid metabolism. The gut microbiome of the DMUA group is different from that of the T2DM group，HUA group or Control group，which may be related to the occurrence and development of T2DM and HUA.