Analysis of the relationship between the levels of S100 calcium ⁃ binding protein,Hcy and neuron ⁃ specific enolase in peripheral blood and the absorption of intracranial hematoma and cognitive function in patients with traumatic craniocerebral injury
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摘要:
目的：探究外周血S100钙结合蛋白、同型半胱氨酸(homocysteine，Hcy)及神经元特异性烯醇化酶(neuron specific enolase，NSE)水平与创伤性颅脑损伤患者颅内血肿吸收情况及认知功能的相关性。方法：选取2018年1月—2020年12月南京医科大学附属逸夫医院收治的74例创伤性颅脑损伤患者为观察组，同期于本院体检的75例健康人为对照组，比较两组外周血S100钙结合蛋白、Hcy及NSE水平；根据血肿吸收情况和是否发生认知功能障碍，将观察组分为吸收良好组、吸收不良组或有认知功能障碍组、无认知功能障碍组，分别比较各组间S100钙结合蛋白、Hcy及NSE水平，分析观察组血肿吸收情况、认知功能与外周血S100钙结合蛋白、Hcy及NSE水平的相关性。结果：观察组S100钙结合蛋白、Hcy及NSE水平明显高于对照组；吸收良好组血清中S100钙结合蛋白、Hcy及NSE水平明显低于吸收不良组；血清内S100钙结合蛋白、Hcy及NSE水平互为正相关，且均与血肿吸收水平呈负相关，即血肿吸收越好，血清内指标越低；有认知功能障碍组血清中S100钙结合蛋白、Hcy及NSE 水平明显高于无认知功能障碍组；认知功能障碍和血清内S100钙结合蛋白、Hcy及NSE水平均呈正相关，差异均有统计学意义 (P ＜ 0.05)。结论：创伤性颅脑损伤患者血肿吸收情况和认知功能与外周血中S100钙结合蛋白、Hcy及NSE水平具有明显的相关性，有助于该病的临床诊治。
Abstract:
Objective：To explore the relationship between the levels of S100 calcium binding protein，homocysteine(homocysteine， Hcy)and neuron specific enolase(neuronspecificenolase，NSE)in peripheral blood and the absorption of intracranial hematoma and cognitive function in patients with traumatic craniocerebral injury. Methods：A retrospective analysis was made on 74 patients with traumatic craniocerebral injury treated in our hospital from January 2018 to December 2020 as the observation group，and 75 healthy persons who underwent physical examination in our hospital in the same period were selected as the control group. The levels of S100 calcium binding protein，Hcy and NSE in peripheral blood of the two groups were compared. According to the absorption of hematoma and the occurrence of cognitive impairment，the observation group was divided into good absorption group，poor absorption group or cognitive impairment group and non - cognitive impairment group. The levels of S100 calcium binding protein，Hcy and NSE were compared among the groups. The correlation of hematoma absorption and cognitive function with the levels of S100 calcium binding protein，Hcy and NSE in peripheral blood was analyzed. Results：The levels of S100 calcium binding protein，Hcy and NSE in the observation group were significantly higher than those in the control group，the serum levels of S100 calcium binding protein，Hcy and NSE in the good absorption group were significantly lower than those in the malabsorption group，and the serum levels of S100 calcium binding protein，Hcy and NSE were positively correlated and negatively correlated with the absorption level of hematoma，that is，the better the absorption of hematoma，the lower the serum index. The levels of serum S100 calcium binding protein，Hcy and NSE in patients with cognitive impairment were significantly higher than those without cognitive impairment，and there was a positive correlation between cognitive impairment and serum levels of S100 calcium binding protein，Hcy and NSE(P ＜ 0.05). Conclusion： The hematoma absorption and cognitive function of patients with traumatic craniocerebral injury are significantly correlated with the levels of S100 calcium binding protein，Hcy and NSE in peripheral blood，which is helpful for the clinical diagnosis and treatment of the disease.
