肠道菌群与妊娠相关疾病关系的研究进展
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E-mail:jesse_1982@163.com

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国家重点研发计划(2016YFC1000300);国家自然科学基金面上项目(81970410,81571458);江苏省重大疾病生物资源样本库出生队列子库开放课题(JC2021B024)


Research progress of gut microbiota and pregnancy⁃related diseases
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    摘要:

    肠道菌群是肠道内各类微生物共同构成的与人体存在共生关系的生态系统,这些微生物在人体肠道内参与了代谢、免疫和营养等多种功能,与人体的健康息息相关,与疾病的发生发展过程也有着千丝万缕的联系。妊娠期女性的肠道菌群构成发生了显著改变,肠道菌群失调也被认为在各妊娠相关疾病的发生发展过程中起重要作用。益生菌可改善肠道微环境, 可作为妊娠相关疾病防治的新思路。本文就妊娠期糖尿病、子痫前期、早产、妊娠期肝内胆汁淤积症等常见妊娠相关疾病的孕妇肠道菌群改变及益生菌用于临床防治的有效性进行综述,以期为进一步进行肠道菌群影响孕妇健康的机制研究及益生菌用于临床疾病防治的更高质量研究提供依据。

    Abstract:

    The gut flora is an ecosystem which is composed of various microorganisms in the intestine and has a symbiotic relationship with the human body. These microorganisms participate in various functions such as metabolism,immunity and nutrition in the human intestine,and are closely related to the health of the human body. They are also inextricably linked to the occurrence and development of diseases. The composition of the gut flora of pregnant women has undergone significant changes,and the dysbiosis of the gut flora is also considered important in the occurrence and development of pregnancy-related diseases. Probiotics can improve the intestinal microenvironment and can be used to prevent or treat these pregnancy-related diseases. This article reviews the changes in the gut flora of women with pregnancy - related diseases such as gestational diabetes mellitus,preeclampsia,premature delivery, intrahepatic cholestasis of pregnancy and the effectiveness of probiotics for clinical prevention and treatment. This review is also expected to provide a basis for further research on the mechanism of gut flora affecting the health of pregnant women and higher-quality research on probiotics.

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诸清逸,石中华.肠道菌群与妊娠相关疾病关系的研究进展[J].南京医科大学学报(自然科学版),2022,42(11):1632-1636

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  • 在线发布日期: 2022-11-24
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