The ability of tumor to proliferate indefinitely depends on its unique metabolic mode. It has been confirmed that non - coding RNA has the ability to encode micropeptides/proteins，of which a small number of micropeptides/proteins can participate in the regulation of tumor energy metabolism and play a key role in the occurrence and development of tumors. This article reviews the current research on the relationship between micropeptides/proteins encoded by ncRNA and cancer metabolism，and discusses the mechanism and clinical significance of these functional micropeptides/proteins in tumorigenesis and development. We believe that in- depth understanding of the regulatory mechanism mediated by ncRNA - encoded micropeptides/proteins in tumor metabolic reprogramming will play an important role in cancer diagnosis，treatment and prognosis.