背侧纹状体参与认知功能神经环路信息整合研究进展
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国家自然科学基金重点项目(81930103)


Research progress of dorsal striatum involved in information integration of neural circuits in cognitive function
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    摘要:

    纹状体是中枢神经系统中调节精细运动的重要核团。近年来越来越多的研究表明,背侧纹状体参与了认知相关的非运动性功能。认知功能障碍(cognitive impairment,CI)是一种学习与记忆能力缺失的精神疾病,在许多疾病早期均有发生。 背侧纹状体作为学习记忆信息处理的中转站,整合上游环路释放的谷氨酸能、多巴胺能等神经递质,再通过直接通路与间接通路将信息输出至下游核团参与认知行为。本文立足于背侧纹状体,阐述其结构功能与神经环路机制,结合现有治疗手段,探究背侧纹状体神经环路中潜在的治疗靶点。

    Abstract:

    Striatum is an important nucleus in the central nervous system that regulates fine motor. Accumulated evidences have shown that the dorsal striatum is involved in not only motor functions but also cognition.Cognitive impairment(CI)is a mental disease with learning and memory deficit,which occurs in the early stage of many diseases. As a relay station for learning and memory information processing,the dorsal striatum integrates glutamatergic,or dopaminergic and other neurotransmitters released by the upstream loop,and then outputs information to the downstream nucleus through direct and indirect pathways to participate in cognitive behavior. In this paper,we will expound its structure,or neural circuit mechanism,and explores the potential therapeutic targets in the neural circuit of the dorsal striatum in combination with the existing treatment methods.

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宋恒毅,胥寒,韩峰.背侧纹状体参与认知功能神经环路信息整合研究进展[J].南京医科大学学报(自然科学版),2022,42(12):1759-1766

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  • 在线发布日期: 2022-12-12
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