The roles and potential application perspectives of alveolar type Ⅱ epithelial cells in idiopathic pulmonary fibrosis caused by air pollution
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摘要:
特发性肺纤维化(idiopathic pulmonary fibrosis，IPF)是一种以细胞外基质过度沉积和肺组织结构不可逆性重塑为特征的慢性肺病，空气污染物的吸入暴露可增加IPF的发病风险。肺脏结构复杂，多种细胞参与肺纤维化过程，而肺泡Ⅱ型上皮细胞(alveolar type Ⅱ epithelial cell，AT2)损伤和功能障碍在IPF的发病过程中起到了关键作用。本文围绕IPF相关的空气污染物，侧重阐述AT2细胞在IPF发生发展中的作用及重要机制，并分析了AT2细胞作为IPF诊断生物标志物及干预靶点的可能性，为大气污染防治及人群健康风险评估提供线索。
Abstract:
Idiopathic pulmonary fibrosis(IPF)is a chronic pulmonary disease characterized by excessive deposition of extracellular matrix and irreversible remodeling of lung tissue structure. Inhalation exposure to air pollution can increase the risk of IPF. The lung structure is complex，and a variety of cells participate in the process of pulmonary fibrosis，while the injury and dysfunction of alveolar type Ⅱ epithelial cells(AT2)play a central role in the pathogenesis of IPF. This article summarizes the air pollutants related to IPF， focuses on the role and common mechanism of AT2 cells in the occurrence and development of IPF，analyzes the possibility of AT2 cells as a diagnostic biomarker and intervention target of IPF，to provide clues for air pollution prevention and population health risk assessment.
