Objective：To investigate the time and influencing factors for patients suffering from osteoporosis after stroke. Methods： The medical records of 685 patients diagnosed as stroke in the Rehabilitation Department of Liyang People’s Hospital from January 2010 to January 2017 were screened using retrospective cohort study methods. One hundred and five cases，complying with the standards，were included. According to whether being diagnosed as osteoporosis within 5 years after stroke，they were divided into osteoporosis group and non-osteoporosis group，with 46 and 59 cases in each group. Logistic regression analysis was used to analyze the factors affecting the occurrence of osteoporosis in stroke patients with the outcome of whether osteoporosis occurs within 5 years. Kaplan- Meier survival analysis was applied to calculate the media time of osteoporosis occurrence and 95% confidence interval. Multivariate Cox regression was used to analyze the factors affecting the rate of osteoporosis in stroke patients after stroke. Results：Gender(female) (OR=8.145，95%CI：1.361~48.735，P=0.022)and age(OR=1.263，95%CI：1.135~1.406，P ＜ 0.001)had an effect on the incidence of poststroke osteoporosis. The media time of osteoporosis occurrence was 3.42 years. Age influenced the onset time of poststroke osteoporosis(HR=1.162，95%CI：1.029~1.313，P=0.016). Compared with manual labor，mental labor has an effect on the occurrence time of osteoporosis after stroke(HR=4.256，95% CI：1.447~12.519，P=0.008). Compared with hyperbaric oxygen therapy after stroke，the occurrence time of osteoporosis after stroke is affected by the absence of hyperbaric oxygen therapy(HR=4.418，95%CI： 1.868~10.450，P=0.001). Compared with 0 times of rehabilitation therapy per year，1-2 times of rehabilitation therapy per year has an impact on the occurrence time of poststroke osteoporosis(HR=14.002，95%CI：2.641~74.450，P=0.002). Compared with anti-osteoporosis therapy, the absence of anti-osteoporosis therapy had an impact on the onset time of poststroke osteoporosis(HR=2.306，95%CI：1.088~ 4.889，P=0.029). Conclusion：Female and old age are independent risk factors for osteoporosis in stroke patients. Young age，physical work，hyperbaric oxygen therapy and anti-osteoporosis therapy are beneficial to slow the development of osteoporosis.