Objective：To analyze the clinical characteristics of patients with pulmonary hypertension(PH)according to neutrophil/ lymphocyte ratio(NLR)and red cell distribution width(RDW)combined with multislice spiral CT(MSCT)，and to explore the correlation between the clinical characteristics and the severity of disease. Methods：The clinical data of 124 patients with PH assessed by transthoracic echocardiography(TTE)in the First Affiliated Hospital of Nanjing Medical University from August 2018 to February 2022 were collected as PH group，and data of 120 healthy patients in our hospital during the same period were collected as control group. MSCT，TTE，blood routine examination and other related results were included to comprehensively evaluate the severity of the disease. Results：①Compared with normal control group，NLR，RDW and diameters of the main pulmonary artery(dMPA)，ratio of main pulmonary artery to ascending aorta diameter(rPA) and ascending aortic diameter(AOD) measured by MSCT were significantly increased in PH group，and the differences were statistically significant(P ＜ 0.05). ②Compared with the mild PH group， the NLR，RDW，dMPA and rPA were significantly higher in the moderate and severe PH group，and the differences were statistically significant(P ＜ 0.05). ③The NLR，RDW，dMPA and rPA were positively correlated with systolic pulmonary artery pressure(PASP)， while AOD had no correlation with PASP. ④The NLR，RDW，dMPA and rPA measured by MSCT had better predictive value for the severity of PH. ⑤RDW，dMPA were the risk factors for elevated PASP. Conclusion：For the assessment of the severity of PH，NLR， RDW，dMPA and rPA all have high predictive value，these indicators can be used as common indicators to evaluate the severity of patients’disease. RDW，dMPA are confirmed to be independent predictors of the exacerbation of PH patients.