Vasculogenic mimicry(VM)is a vascular network -like pipeline structure formed by tumor cells through deformation， migration，and matrix remodeling. Glioma is the most common primary malignant tumor in the brain，which is characterized by high vascularization. However，antiangiogenic therapy has not achieved the expected results in the clinical application of glioma，which may be caused by VM. Although its detailed molecular mechanism is unclear，accumulating evidences showed that the tumor microenvironment plays an important role in the development of glioma VM. Here，we reviewed the recent progresses in the influence of tumor microenvironment on VM formation and its pharmacological significance in the treatment of glioma. We also raise some issues that should be focused on in future research.