环境内分泌干扰物与甲状腺疾病关系的研究进展
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中国健康促进基金会“甲状腺中青年医生研究项目”[2019(PB19)];伊犁州临床医学研究院研究基金(yl2021ms03);江苏省科教能力提升工程江苏省医学重点学科(ZDXK202202)


Research advances in the relationship between environmental endocrine disrupting chemicals and thyroid disease
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    摘要:

    环境内分泌干扰物广泛存在于人们的生产生活环境中,其种类繁多,不仅干扰人体的生殖、神经、免疫等系统,更是对体内最大的内分泌器官——甲状腺产生不可忽视的影响。然而,以往研究多从甲状腺激素和甲状腺的组织病理学入手,很少从自身免疫性甲状腺疾病和甲状腺癌的角度切入。本文通过系统回顾,阐述了几种常见的环境内分泌干扰物在自身免疫性甲状腺疾病和甲状腺癌发生发展过程中的作用,包括诱导抗甲状腺自身抗体产生和影响T细胞分化等,为研究自身免疫性甲状腺疾病和甲状腺癌的潜在环境暴露危险因素提供依据,对该类疾病的防治有积极意义。

    Abstract:

    Environmental endocrine disrupting chemicals(EDC)are widespread in people’s production and living environment. Due to a wide variety of endocrine disruptors,they not only interfere with human reproductive system,nervous system and immune system,but also exert a non-negligible influence on the thyroid,which is the largest endocrine organ in the body. The previous studies mostly focused on thyroid hormone and histopathology,and few reports were available on the associations between autoimmune thyroid diseases(AITD)or thyroid cancer(TC)and EDC. Therefore,the current review elucidates the potential adverse effects of EDC on thyroid,especially in autoimmune thyroid diseases and thyroid cancer,including induction of thyroid autoantibodies and the effect on T cell differentiation,etc.,which may provide a basis for the study of the potential environmental exposure risk factors of autoimmune thyroid diseases and thyroid cancer,and has positive significance on prevention and treatment of these diseases.

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段欣洁,王军,王子骁,陈欢欢.环境内分泌干扰物与甲状腺疾病关系的研究进展[J].南京医科大学学报(自然科学版),2023,(3):427-431

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  • 在线发布日期: 2023-03-11
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