血管周围脂肪与心血管疾病的研究进展
作者:
中图分类号:

R541.8

基金项目:

江苏省卫生健康委员会基金(BJ20013)


Research progress of perivascular adipose tissue and cardiovascular disease
Author:
  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献 [54]
  • |
  • 相似文献 [20]
  • | | |
  • 文章评论
    摘要:

    在人体中,存在着一种围绕着除脑血管外的所有心血管的脂肪组织,称为血管周围脂肪(perivascular adipose tis- sue,PVAT)。近年来,由于其位置及功能的特殊性,PVAT被视为一种不同于传统内脏脂肪的新型脂肪组织,可通过旁分泌、内分泌具有促进血管舒缩功能的脂肪因子,介导免疫炎症反应及脂肪细胞表型转换等途径,对心血管系统产生双面性的影响,包括在生理状态下对心血管的保护作用及病理状态下促心血管疾病(cardiovascular disease,CVD)发生的不良作用。而通过对 PVAT的实验室及影像学检查与干预,有助于提高对心血管疾病的诊断能力、增加具有可行性的治疗手段。本文将叙述PVAT 与经典脂肪类型的区别,其生理、病理情况下对心血管系统的影响及在心血管疾病诊疗中的作用。

    Abstract:

    For the past few years,a unique type of adipose tissue,surrounding our cardiovascular system but cerebrovascular, known as perivascular adipose tissue(PVAT),has been seen as a new kind of adipose tissue different from the classic visceral fat due to its unusual anatomic location and function. PVAT exerts a bidirectional effect on the cardiovascular system,including the protectional role under physiological state and the deleterious influence under pathological state,through the release of vasoconstrictive/ relaxant adipokine in a paracrine/endocrine manner,the induction of inflammation and phenotypic transformation of adipocytes. PVAT also shows a potential role in the diagnosis and treatment of cardiovascular disease(CVD)as a new parameter and intervention. In this review,we will discuss the characteristics of PVAT to distinguish from classic adipose tissue and its effect on CVD under physiology/ pathology conditions,also,its application in CVD diagnosis and treatment.

    参考文献
    [1] GREGG E W,SHAW J E.Global health effects of over⁃weight and obesity[J].N Engl J Med,2017,377(1):80-81
    [2] COLLABORATORS G B D O,AFSHIN A,FOROUZAN⁃FAR M H,et al.Health effects of overweight and obesityin 195 countries over 25 years[J].N Engl J Med,2017,377(1):13-27
    [3] AHMED B,SULTANA R,GREENE M W.Adipose tissueand insulin resistance in obese[J].Biomed Pharmacoth⁃er,2021,137:111315
    [4] 季学涛,张许,刘谨,等.脂肪组织中自噬影响肥胖发病机制的研究进展[J].南京医科大学学报(自然科学版),2023,43(2):275-282
    [5] 蔡锦锋,俞静,张文娜,等.甲状腺激素合成代谢与人体内脏脂肪米色化基因表达的相关性[J].南京医科大学学报(自然科学版),2022,42(5):679-683
    [6] SAXTON S N,CLARK B J,WITHERS S B,et al.Mecha⁃nistic links between obesity,diabetes,and blood pres⁃sure:role of perivascular adipose tissue[J].Physiol Rev,2019,99(4):1701-1763
    [7] REYES ⁃FARIAS M,FOS ⁃DOMENECH J,SERRA D,etal.White adipose tissue dysfunction in obesity and aging[J].Biochem Pharmacol,2021,192:114723
    [8] QI X Y,QU S L,XIONG W H,et al.Perivascular adiposetissue(PVAT)in atherosclerosis:a double ⁃ edged sword[J].Cardiovasc Diabetol,2018,17(1):134
    [9] GALLEY J C,SINGH S,AWATA W M C,et al.Adipo⁃kines:deciphering the cardiovascular signature of adiposetissue[J].Biochem Pharmacol,2022,206:115324
    [10] LONGO M,ZATTERALE F,NADERI J,et al.Adipose tis⁃sue dysfunction as determinant of obesity⁃associated meta⁃bolic complications[J].Int J Mol Sci,2019,20(9):2358
    [11] CHANG L,VILLACORTA L,LI R,et al.Loss of perivas⁃cular adipose tissue on peroxisome proliferator ⁃ activatedreceptor ⁃ gamma deletion in smooth muscle cells impairsintravascular thermoregulation and enhances atherosclero⁃sis[J].Circulation,2012,126(9):1067⁃1078
    [12] KALISZ M,CHMIELOWSKA M,MARTYNSKA L,et al.All ⁃ trans ⁃ retinoic acid ameliorates atherosclerosis,pro⁃motes perivascular adipose tissue browning,and increasesadiponectin production in Apo⁃E mice[J].Sci Rep,2021,11(1):4451
    [13] 陈叶飞,吴旦斌,杨正飞,等.血管周围脂肪组织中脂肪细胞不同亚型的转化与动脉粥样硬化关系的研究进展[J].四川医学,2019,40(12):1285-1289
    [14] SAXTON S N,RYDING K E,ALDOUS R G,et al.Role ofsympathetic nerves and adipocyte catecholamine uptakein the vasorelaxant function of perivascular adipose tissue[J].Arterioscler Thromb Vasc Biol,2018,38(4):880-891
    [15] HILDEBRAND S,STUMER J,PFEIFER A.PVAT and itsrelation to brown,beige,and white adipose tissue in devel⁃opment and function[J].Front Physiol,2018,9:70
    [16] CHENG K K,LAM K S,WANG Y,et al.Adiponectin⁃in⁃duced endothelial nitric oxide synthase activation and ni⁃tric oxide production are mediated by APPL1 in endotheli⁃al cells[J].Diabetes,2007,56(5):1387-1394
    [17] CHENG C K,BAKAR H A,GOLLASCH M,et al.Perivas⁃cular adipose tissue:the sixth man of the cardiovascularsystem[J].Cardiovasc Drugs Ther,2018,32(5):481-502
    [18] ANSALDO A M,MONTECUCCO F,SAHEBKAR A,etal.Epicardial adipose tissue and cardiovascular diseases[J].Int J Cardiol,2019,278:254-260
    [19] LIN S,LI X,ZHANG J,et al.Omentin ⁃1:protective im⁃pact on ischemic stroke via ameliorating atherosclerosis[J].Clin Chim Acta,2021,517:31-40
    [20] KUMAR R K,JIN Y,WATTS S W,et al.Naive,regulatory,activated,and memory immune cells Co ⁃ exist in PVATsthat are comparable in density to Non⁃PVAT fats in health[J].Front Physiol,2020,11:58
    [21] CORKEN A,THAKALI K M.Maternal obesity program⁃ming of perivascular adipose tissue and associated im⁃mune cells:an understudied area with few answers andmany questions[J].Front Physiol,2021,12:798987
    [22] KONWERSKI M,GASECKA A,OPOLSKI G,et al.Roleof epicardial adipose tissue in cardiovascular diseases:areview[J].Biology(Basel),2022,11(3):355
    [23] IACOBELLIS G.Aging effects on epicardial adipose tissue[J].Front Aging,2021,2:666260
    [24] MU W,QIAN S,SONG Y,et al.BMP4⁃mediated brown⁃ing of perivascular adipose tissue governs an anti⁃inflam⁃matory program and prevents atherosclerosis[J].RedoxBiol,2021,43:101979
    [25] NARYZHNAYA N V,KOSHELSKAYA O A,KOLOG⁃RIVOVA I V,et al.Production of reactive oxygen speciesby epicardial adipocytes is associated with an increase inpostprandial glycemia,postprandial insulin,and adecrease in serum adiponectin in patients with severe cor⁃onary atherosclerosis[J].Biomedicines,2022,10(8):2054
    [26] JUAN C C,CHUANG T Y,LIEN C C,et al.Leptin in⁃creases endothelin type A receptor levels in vascularsmooth muscle cells[J].Am J Physiol Endocrinol Metab,2008,294(3):E481⁃487
    [27] HALL J E,DO CARMO J M,DA SILVA A A,et al.Obesi⁃ty,kidney dysfunction and hypertension:mechanisticlinks[J].Nat Rev Nephrol,2019,15(6):367-385
    [28] BELTOWSKI J.Leptin and the regulation of endothelialfunction in physiological and pathological conditions[J].Clin Exp Pharmacol Physiol,2012,39(2):168-178
    [29] JUNG H N,JUNG C H.The role of anti⁃inflammatory adi⁃pokines in cardiometabolic disorders:moving beyond adi⁃ponectin[J].Int J Mol Sci,2021,22(24):13529
    [30] TAYLOR C T,SCHOLZ C C.The effect of HIF on metab⁃olism and immunity[J].Nature Reviews Nephrology,2022,18(9):573-587
    [31] KOCHUMON S,AREFANIAN H,SINDHU S,et al.Ex⁃pression of steroid receptor RNA activator 1(SRA1)inthe adipose tissue is associated with TLRs and IRFs indiabesity[J].Cells,2022,11(24):4007
    [32] TRIPATHI Y B,PANDEY V.Obesity and endoplasmic re⁃ticulum(ER)stresses[J].Front Immunol,2012,3:240
    [33] MAIELLARO K,TAYLOR W R.The role of the adventi⁃tia in vascular inflammation[J].Cardiovasc Res,2007,75(4):640-648
    [34] KOENEN M,HILL M A,COHEN P,et al.Obesity,adi⁃pose tissue and vascular dysfunction[J].Circ Res,2021,128(7):951-968
    [35] EVANS B R,YERLY A,VAN DER VORST E P C,et al.Inflammatory mediators in atherosclerotic vascular remod⁃eling[J].Front Cardiovasc Med,2022,9:868934
    [36] NISHIMURA S,MANABE I,NAGASAKI M,et al.CD8 +effector T cells contribute to macrophage recruitment andadipose tissue inflammation in obesity[J].Nat Med,2009,15(8):914-920
    [37] 韩婷婷,穆玥,洪叶,等.CCTA定量斑块特征及血管周围脂肪在急性冠脉综合征中的临床价值[J].放射学实践,2021,36(3):361-365
    [38] YERRAMASU A,DEY D,VENURAJU S,et al.Increasedvolume of epicardial fat is an independent risk factor foraccelerated progression of sub ⁃ clinical coronary athero⁃sclerosis[J].Atherosclerosis,2012,220(1):223-230
    [39] RUSSO R,DI IORIO B,DI LULLO L,et al.Epicardial ad⁃ipose tissue:new parameter for cardiovascular risk assess⁃ment in high risk populations[J].J Nephrol,2018,31(6):847-853
    [40] ITO T,SUZUKI Y,EHARA M,et al.Impact of epicardialfat volume on coronary artery disease in symptomatic pa⁃tients with a zero calcium score[J].Int J Cardiol,2013,167(6):2852-2858
    [41] OKUBO R,NAKANISHI R,TODA M,et al.Pericoronaryadipose tissue ratio is a stronger associated factor ofplaque vulnerability than epicardial adipose tissue on cor⁃onary computed tomography angiography[J].Heart Ves⁃sels,2017,32(7):813-822
    [42] LIBBY P.The changing landscape of atherosclerosis[J].Nature,2021,592(7855):524-533
    [43] LEE S E,SUNG J M,ANDREINI D,et al.Association be⁃tween changes in perivascular adipose tissue density andplaque progression[J].JACC Cardiovasc Imaging,2022,15(10):1760-1767
    [44] HEDGIRE S,BALIYAN V,ZUCKER E J,et al.Perivas⁃cular epicardial fat stranding at coronary CT angiography:a marker of acute plaque rupture and spontaneous coronaryartery dissection[J].Radiology,2018,287(3):808-815
    [45] QIN B,LI Z,ZHOU H,et al.The predictive value of theperivascular adipose tissue CT fat attenuation index forcoronary in ⁃ stent restenosis[J].Front Cardiovasc Med,2022,9:822308
    [46] 付慧,周灿灿,李冬洁,等.腹主动脉瘤的研究进展:病理机制及动物模型[J].中国医学科学院学报,2022,44(3):516-520
    [47] YE T,ZHANG G,LIU H,et al.Relationships betweenperivascular adipose tissue and abdominal aortic aneu⁃rysms[J].Front Endocrinol(Lausanne),2021,12:704845
    [48] DIAS⁃NETO M,MEEKEL J P,VAN SCHAIK T G,et al.High density of periaortic adipose tissue in abdominal aor⁃tic aneurysm[J].Eur J Vasc Endovasc Surg,2018,56(5):663-671
    [49] WANG X,HE B,DENG Y,et al.Identification of a bio⁃marker and immune infiltration in perivascular adiposetissue of abdominal aortic aneurysm[J].Front Physiol,2022,13:977910
    [50] GUO C,LIU Z,YU Y,et al.EGR1 and KLF4 as diagnos⁃tic markers for abdominal aortic aneurysm and associatedwith immune infiltration[J].Front Cardiovasc Med,2022,9:781207
    [51] HUANG C L,HUANG Y N,YAO L,et al.Thoracic peri⁃vascular adipose tissue inhibits VSMC apoptosis and aor⁃tic aneurysm formation in mice via the secretome ofbrowning adipocytes[J].Acta Pharmacol Sin,2023,44(2):345-355
    [52] ADACHI Y,UEDA K,NOMURA S,et al.Beiging of peri⁃vascular adipose tissue regulates its inflammation and vas⁃cular remodeling[J].Nat Commun,2022,13(1):5117
    [53] AGHAMOHAMMADZADEH R,GREENSTEIN A S,YA⁃DAV R,et al.Effects of bariatric surgery on human smallartery function:evidence for reduction in perivascular adi⁃pocyte inflammation,and the restoration of normal anti⁃contractile activity despite persistent obesity[J].J AmColl Cardiol,2013,62(2):128-135
    [54] SHI N,XIA J,WANG C,et al.Aerobic exercise preventsarterial stiffness and attenuates hyperexcitation of sympa⁃thetic nerves in perivascular adipose tissue of mice aftertransverse aortic constriction[J].Int J Mol Sci,2022,23(19):11189
    引证文献
引用本文

张文娜,朱浩,王晓东.血管周围脂肪与心血管疾病的研究进展[J].南京医科大学学报(自然科学版),2023,(5):725-731

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2023-02-13
  • 在线发布日期: 2023-05-18
关闭