Peptides are bioactive substances involved in various cellular functions in the human body，mainly derived from two pathways：amino acid dehydration condensation and protein degradation. All cells can synthesize peptide substances，and cell function activities are also regulated by peptides. Peptidomics based on mass spectrometry has been applied in disease diagnosis and treatment. A few related studies have also begun to explore the pathogenesis of gynecological and obstetric diseases，such as ovarian cancer， preeclampsia，gestational diabetes mellitus，cervical cancer，endometriosis，etc. Therefore，it is of great clinical significance to study peptidomics to explore the potential pathogenesis and biomarkers of these obstetrics and gynecology diseases.