颈动脉内中膜厚度与亚临床左心室收缩功能的关系
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R540.45;R540.48

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江苏省重点研发计划社会发展项目(BE2021752);江苏省中医高血压病临床医学创新中心重点项目(k2021j17-4); 江苏省中医院高峰人才项目(y2021rc15)


Association between carotid intima⁃media thickness and subclinical left ventricular systolic function
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    摘要:

    目的:在江苏丹阳社区人群中探讨颈动脉内中膜厚度(carotid intima-media thickness,cIMT)与亚临床左心室功能的关系。方法:研究对象为2021年在江苏省丹阳市车站社区招募的受试者。使用GE Vivid E90超声仪测量分析cIMT;二维斑点追踪技术采集左心室整体纵向应变(left ventricular global longitudinal strain,LVGLS)作为评估亚临床收缩功能的指标,二尖瓣口血流频谱和组织多普勒成像采集e’和E/e’比值作为评估亚临床舒张功能的指标。结果:研究共计纳入561例,年龄 (58.2±11.7)岁,其中女339例(60.4%)。首先使用三分位法将cIMT作为分类变量分析,在单因素分析中,除了左心室射血分数外,LVGLS,E/A和e’均随着cIMT三分位数从低到高下降,而E/e’比值随着cIMT三分位数从低到高增加(均Ptrend ≤ 0.002)。然而,进一步进行多因素校正分析后,只有LVGLS仍随着cIMT三分位数从低到高下降(P < 0.05)。进一步将cIMT自然对数转换后进行连续变量分析,结果与分类变量分析结果类似,仅有LVGLS与cIMT显著负相关(r=-0.087,P=0.041);并且在回归分析中也发现了类似的结果(β=-1.12,P=0.041)。结论:在江苏丹阳社区人群中,cIMT增厚与GLS减低独立相关。

    Abstract:

    Objective:To explore the relationship between carotid intima -media thickness(cIMT)and subclinical left ventricular function in population of Danyang community. Methods:The study subjects were recruited in 2021 from the Station Community of Danyang City,Jiangsu Province. cIMT was measured and analyzed by GE Vivid E90 ultrasound instrument. Two-dimensional(2D) speckle tracking technology was used to collect left ventricular global longitudinal strain(LVGLS)of the left ventricle as an indicator for assessing subclinical systolic function. The e’and E/e’ratio were obtained from mitral valve blood flow spectra and tissue Doppler imaging,serving as indicators for evaluating subclinical diastolic function. Results:A total of 561 participants with an average age of (58.2 ± 11.7)years were enrolled,among whom 339(60.4% )were females. Using tertiles of cIMT as a categorical variable,in univariate analysis,LVGLS,E/A ratio,and e’decreased as cIMT tertiles increased,while the E/e’ratio increased(all Ptrend ≤ 0.002), except for left ventricular ejection fraction. However,after further multivariate adjustment,only LVGLS continued to decrease with increasing cIMT tertiles(P < 0.05). Continuous variable analysis after natural logarithm transformation of cIMT yielded results similar to categorical variable analysis,with only LVGLS showing a significant negative correlation with cIMT(r=- 0.087,P=0.041),and similar findings were observed in regression analysis(β =- 1.12,P=0.041). Conclusion:In the Danyang community population in Jiangsu,increased cIMT is independently correlated with decreased GLS.

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李一博,张雪,梁君雅,花木莲,张思奇,高云,陈超,赵熙璇,何姗姗,王新月,周天娜,何安霞,刘鸣.颈动脉内中膜厚度与亚临床左心室收缩功能的关系[J].南京医科大学学报(自然科学版),2024,(4):491-498,510

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  • 收稿日期:2023-11-19
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  • 在线发布日期: 2024-04-11
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