Chronic obstructive pulmonary disease(COPD),the third leading cause of death worldwide,is a chronic inflammatory airway disease characterized by incompletely reversible airflow limitations. The pathogenesis of COPD is complex,and the specific mechanisms are still unclear. Extracellular vesicles(EVs),including exosomes,microvesicles(MVs),and apoptotic bodies(ABs), carry various proteins,lipids,DNA,mRNA and microRNA,and other cell-derived components,participating in processes such as intercellular communication,cell migration,angiogenesis,and immune regulation. In recent years,the role of EVs in pulmonary diseases has attracted significant attention. This article provides a review of recent studies on the relationships between EVs and COPD.