Advances in the clinical application of dedicated breast PET in breast cancer
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摘要:
乳腺癌是目前世界范围内发病率最高的肿瘤,早发现、早诊断对于乳腺癌患者的治疗及预后具有重要意义。乳腺专用PET(dedicated breast PET,dbPET)是一种新兴的分子成像设备,在临床实践中用于乳腺癌的检测和肿瘤生物学的评估,具有比传统影像学手段更高的空间分辨率,可以识别乳房内放射性示踪剂摄取的详细形态学模式。鉴于国内外对dbPET的综合性分析较少,文章从dbPET在乳腺癌的筛查、诊断、摄取模式、新辅助化疗后评估及PET显像剂等方面的应用进行综述。
Abstract:
Breast cancer is currently the most common tumor worldwide,and early detection and diagnosis are of great significance for the treatment and prognosis of breast cancer patients. Dedicated breast PET(dbPET)is an emerging molecular imaging device that has been used in clinical practice for the detection of breast cancer and the assessment for tumor biology. It has higher spatial resolution than conventional imaging modalities and can identify detailed morphological patterns of radiotracer uptake within the breast. There have been few comprehensive analysis of dbPET both domestically and internationally. In this paper,we review dbPET in breast cancer screening,diagnosis,uptake patterns,assessment after neoadjuvant chemotherapy,and PET imaging agents to provide a systematic understanding of dbPET.