1.蚌埠医科大学第一附属医院神经内科，安徽 蚌埠 233004 ;2.苏北人民医院神经内科，江苏 扬州 225001
R742.5
扬州市科技技术项目（YZ2022203）
1.Department of Neurology，the First Affiliated Hospital of Bengbu Medical University，Bengbu 233004 ;2.Department of Neurology，Northern Jiangsu People’s Hospital，Yangzhou 225001 ，China
目的：探索颈动脉内膜中层厚度（carotid intima-media thickness，CIMT）和颈动脉斑块与帕金森病（Parkinson’s dis- ease，PD）患者认知障碍的相关性。方法：根据蒙特利尔认知评价量表，将225例PD患者分为3组：认知功能正常（normal cogni- tive function，NC）组41例、轻度认知功能障碍（mild cognitive impairment，MCI）组76例和痴呆（Parkinson’s disease with dementia， PDD）组108例。比较3组患者间临床资料及颈动脉超声等指标的差异，使用多元线性回归分析PD认知障碍的影响因素。结果：与NC组比较，MCI和PDD组的教育水平下降（P均< 0.05），Hoehn-Yahr分级、统一帕金森病评定量表第三部分（unified Par- kinson disease rating scale-Ⅲ，UPDRS-Ⅲ）、汉密尔顿抑郁量表、匹兹堡睡眠质量指数量表、胱抑素C水平、CIMT、颈动脉斑块易损性积分上升（P均< 0.05）。回归分析显示教育水平高是PD认知障碍的保护因素（P < 0.001），而CIMT增厚、Hoehn-Yahr分级高是PD认知障碍的独立危险因素（P=0.002、P=0.001）。结论：颈动脉粥样硬化与PD认知障碍存在相关性。
Objective：To investigate whether carotid intima-media thickness（CIMT）and carotid plaque are associated with cognitive impairment in patients with Parkinson’s disease（PD）. Methods：According to the Montreal Cognitive Assessment Scale，225 PD patients were divided into three groups：the normal cognitive function（NC）group（n=41），the mild cognitive impairment（MCI） group（n=76），and the Parkinson’s disease with dementia（PDD）group（n=108）. Clinical characteristics and carotid ultrasound parameters were compared among the groups. Multivariate linear regression analysis was used to identify factors influencing cognitive impairment in PD. Results：Compared with the NC group，the MCI and PDD groups showed lower education levels（all P < 0.05）and higher Hoehn-Yahr（H&Y）stage，unified Parkinon disease rating scale-Ⅲ（UPDRS-Ⅲ），Hamilton depression scale，Pittsburgh sleep quality index scale，cystatin C level，CIMT，carotid plaque detection rate，and carotid plaque vulnerability scores（all P < 0.05）. Regression analysis showed that high education level was an independent protective factor for PD cognitive impairment（P < 0.001）， while CIMT thickness（P=0.002）and high H&Y（P=0.001）stage were independent risk factors for PD cognitive impairment. Conclusion：Carotid atherosclerosis is associated with cognitive impairment in PD patients.
彭利亚,徐耀,乔婷婷,马灿灿,陈兰兰.颈动脉内膜中层厚度与帕金森病认知功能障碍的相关性研究[J].南京医科大学学报（自然科学版）,2025,(3):389-395
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