颈动脉内膜中层厚度与帕金森病认知功能障碍的相关性研究
作者:
作者单位:

1.蚌埠医科大学第一附属医院神经内科,安徽 蚌埠 233004 ;2.苏北人民医院神经内科,江苏 扬州 225001

中图分类号:

R742.5

基金项目:

扬州市科技技术项目(YZ2022203)


Study on the correlation between carotid intima⁃media thickness and cognitive impairment in Parkinson’s disease
Author:
Affiliation:

1.Department of Neurology,the First Affiliated Hospital of Bengbu Medical University,Bengbu 233004 ;2.Department of Neurology,Northern Jiangsu People’s Hospital,Yangzhou 225001 ,China

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    摘要:

    目的:探索颈动脉内膜中层厚度(carotid intima-media thickness,CIMT)和颈动脉斑块与帕金森病(Parkinson’s dis- ease,PD)患者认知障碍的相关性。方法:根据蒙特利尔认知评价量表,将225例PD患者分为3组:认知功能正常(normal cogni- tive function,NC)组41例、轻度认知功能障碍(mild cognitive impairment,MCI)组76例和痴呆(Parkinson’s disease with dementia, PDD)组108例。比较3组患者间临床资料及颈动脉超声等指标的差异,使用多元线性回归分析PD认知障碍的影响因素。结果:与NC组比较,MCI和PDD组的教育水平下降(P均< 0.05),Hoehn-Yahr分级、统一帕金森病评定量表第三部分(unified Par- kinson disease rating scale-Ⅲ,UPDRS-Ⅲ)、汉密尔顿抑郁量表、匹兹堡睡眠质量指数量表、胱抑素C水平、CIMT、颈动脉斑块易损性积分上升(P均< 0.05)。回归分析显示教育水平高是PD认知障碍的保护因素(P < 0.001),而CIMT增厚、Hoehn-Yahr分级高是PD认知障碍的独立危险因素(P=0.002、P=0.001)。结论:颈动脉粥样硬化与PD认知障碍存在相关性。

    Abstract:

    Objective:To investigate whether carotid intima-media thickness(CIMT)and carotid plaque are associated with cognitive impairment in patients with Parkinson’s disease(PD). Methods:According to the Montreal Cognitive Assessment Scale,225 PD patients were divided into three groups:the normal cognitive function(NC)group(n=41),the mild cognitive impairment(MCI) group(n=76),and the Parkinson’s disease with dementia(PDD)group(n=108). Clinical characteristics and carotid ultrasound parameters were compared among the groups. Multivariate linear regression analysis was used to identify factors influencing cognitive impairment in PD. Results:Compared with the NC group,the MCI and PDD groups showed lower education levels(all P < 0.05)and higher Hoehn-Yahr(H&Y)stage,unified Parkinon disease rating scale-Ⅲ(UPDRS-Ⅲ),Hamilton depression scale,Pittsburgh sleep quality index scale,cystatin C level,CIMT,carotid plaque detection rate,and carotid plaque vulnerability scores(all P < 0.05). Regression analysis showed that high education level was an independent protective factor for PD cognitive impairment(P < 0.001), while CIMT thickness(P=0.002)and high H&Y(P=0.001)stage were independent risk factors for PD cognitive impairment. Conclusion:Carotid atherosclerosis is associated with cognitive impairment in PD patients.

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彭利亚,徐耀,乔婷婷,马灿灿,陈兰兰.颈动脉内膜中层厚度与帕金森病认知功能障碍的相关性研究[J].南京医科大学学报(自然科学版),2025,(3):389-395

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  • 收稿日期:2024-06-24
  • 在线发布日期: 2025-03-17
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