基于CT上肿瘤⁃胸膜位置关系预测肺腺癌患者隐匿性纵隔淋巴结转移的临床价值
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1.南京医科大学第一附属医院放射科 ;2.病理科,江苏 南京 210029

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江苏省卫生健康委科研项目(K2023057)


The clinical value of imaging model based on tumor ⁃ pleura relationship on CT for predicting occult mediatinal lymph node metastasis in lung adenocarcinoma
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1.Department of Radiology ;2.Department of Pathology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029 ,China

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    摘要:

    目的:基于肺腺癌原发灶的临床及影像学特征构建肺腺癌隐匿性纵隔淋巴结转移的预测模型。方法:回顾性分析南京医科大学第一附属医院2009—2019年行手术治疗和淋巴结清扫、病理结果为有/无隐匿性纵隔淋巴结转移的肺腺癌患者, 收集患者的多个临床及影像学特征。采用单因素和多因素Logistic回归分析筛选独立预测因子,并构建多个CT特征的影像模型。建立受试者工作特征(receiver operating characteristic,ROC)曲线评估各模型的预测效能和临床实用价值。结果:在最终纳入的780例肺腺癌伴大小正常的淋巴结患者中,145例发生淋巴结转移。单因素分析结果提示,肿瘤大小、轴向位置、结节性质、形态学特征、胸膜牵拉征、胸膜毗邻类型与淋巴结转移显著相关。多因素分析结果提示,肿瘤大小(OR=1.019,95%CI: 1.002~1.036,P=0.028)、结节性质(OR=0.361,95%CI:0.202~0.646,P=0.001)、胸膜牵拉(OR=1.835,95%CI:1.152~2.924,P= 0.011)和纵隔胸膜毗邻(OR=1.796,95%CI:1.106~2.919,P=0.018)是隐匿性纵隔淋巴结转移的独立预测因子。基于预测因子建立的影像学模型,ROC曲线下面积(area under the curve,AUC)为0.75,灵敏度为86.2%,特异度为53.1%。结论:基于胸部CT 平扫建立的影像学特征模型,在预测肺腺癌隐匿性纵隔淋巴结转移上具有较好的临床价值,可为临床医生的无创性术前决策及手术治疗方案选择提供依据。

    Abstract:

    Objective:To construct a predictive model for occult mediastinal lymph node metastasis in lung adenocarcinoma based on clinical and imaging features of the primary tumor. Methods:A retrospective analysis was conducted on lung adenocarcinoma patients,who underwent surgical treatment and lymph node dissection with or without occult mediastinal lymph node metastasis on pathology at the First Affiliated Hospital of Nanjing Medical University from 2009 to 2019. Multiple clinical and imaging features of the patient were collected. Univariate and multivariate logistic regression analyses were used to identify independent predictors,and an imaging model incorporating multiple CT characteristics was constructed. Receiver operating characteristic(ROC)curves were established to evaluate the predictive efficacy and clinical utility value of each model. Results:Among the final 780 patients with normal-sized lymph nodes,145 cases exhibited lymph node metastasis. Univariate analysis suggested that tumor size,axial location, nodule characteristics,morphological features,pleural pulling sign,and type of pleural adjacency were significantly associated with lymph node metastasis. Multivariate analysis indicated that tumor size(OR=1.019,95% CI:1.002- 1.036,P=0.028),nodule characteristics(OR=0.361,95% CI:0.202-0.646,P=0.001),pleural tag(OR=1.835,95%CI:1.152-2.924,P=0.011),and presence of mediastinal pleural abutting(OR=1.796,95% CI:1.106- 2.919,P=0.018)were independent predictors of occult mediastinal lymph node metastasis. The imaging model developed based on these predictors showed an area under the curve(AUC)of 0.75,with a sensitivity of 86.2% and specificity of 53.1%. Conclusion:The imaging model based on chest CT scans demonstrates excellent clinical value in predicting occult mediastinal lymph node metastasis in lung adenocarcinoma. It provides a basis for non-invasive preoperative decision making and surgical treatment planning by clinicians.

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郝沁敏,贾亦真,李海,俞同福,徐海,袁梅.基于CT上肿瘤⁃胸膜位置关系预测肺腺癌患者隐匿性纵隔淋巴结转移的临床价值[J].南京医科大学学报(自然科学版),2025,(4):463-470

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  • 收稿日期:2024-12-12
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  • 在线发布日期: 2025-04-08
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