Triple-negative breast cancer（TNBC）is a subtype of breast cancer with negative expression of estrogen receptor（ER）， progesterone receptor（PR）and human epidermal growth factor receptor 2（HER 2），which has extensive tumor heterogeneity at the pathological and molecular levels，and strong invasive and metastatic abilities. Currently，the treatment regimens for TNBC are not satisfactory，and there is a high possibility of recurrence and metastasis after treatment. Sonodynamic therapy（SDT），due to its non - invasiveness and high tissue penetration ability，has been gradually introduced into the research on the treatment of various cancers. This article briefly introduces the basic principle of SDT and the current research progress on the treatment of TNBC based on SDT.