基于甲襞微循环特征的结缔组织病患者肺动脉高压风险评估研究
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1南京医科大学第一附属医院风湿免疫科,2心血管内科,江苏 南京 210029

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R544.1;R593.2

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国家重点基础研究发展计划(2021YFC2501305)


Exploring the risk of pulmonary arterial hypertension in patients with connective tissue disease based on nailfold video capillaroscopy
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1Department of Rheumatology,2Department of Cardiology,the First Affiliated Hospital with Nanjing MedicalUniversity,Nanjing 210029 ,China

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    摘要:

    目的:本研究旨在评估甲襞微循环检测(nailfold video capillaroscopy,NVC)在结缔组织病(connective tissue disease, CTD)相关肺动脉高压(pulmonary arterial hypertension,PAH)患者诊断中的预测价值。方法:回顾性分析2022年9月—2024年6 月在南京医科大学第一附属医院风湿免疫科住院并行NVC的CTD患者147例。根据是否合并PAH,将患者分为CTD-PAH和 CTD-nonPAH两组。通过多因素Logistic回归分析筛选CTD患者发生PAH的危险因素。基于该多因素Logistic回归分析构建 Nomogram预测模型,并使用受试者工作特征曲线(receiver operating characteristic,ROC)进行模型性能评估。结果:CTD患者中 CTD-PAH 组 52 例(35.4%)。CTD-PAH 组患者的毛细血管袢长度较 CTD-nonPAH 组长[262.0(207.0,308.0)vs. 202.0(160.0, 272.0),P < 0.05],袢周积分高于CTD-nonPAH组[2.40(0.80,3.92)vs. 1.90(0.40,2.80),P < 0.05]。Logistic回归分析显示管袢长度长和袢周积分高均增加PAH发生的风险[OR=1.300(95%CI:1.100~1.500),OR=1.268(95%CI:1.025~1.568)]。Nomogram 预测模型ROC曲线下面积达0.705(95%CI:0.618~0.792,P < 0.05)。结论:甲襞毛细血管特征(包括毛细血管袢长度和袢周积分) 可能是结缔组织病患者发生肺动脉高压的独立预测因子,为CTD-PAH患者的早期筛查和个体化治疗策略提供了新的依据。

    Abstract:

    Objective:This study aims to evaluate the predictive value of nailfold capillaroscopy(NVC)in the diagnosis of patients with connective tissue disease(CTD)associated pulmonary arterial hypertension(PAH). Methods:A retrospective analysis was conducted on 147 patients with connective tissue disease(CTD)who were hospitalised in the Department of Rheumatology and Immunology of the First Affiliated Hospital with Nanjing Medical University and underwent NVC from September 2022 to June 2024. According to whether they were combined with pulmonary arterial hypertension(PAH)or not,CTD patients were divided into two groups:CTD - PAH and CTD - nonPAH. Risk factors for PAH in CTD patients were screened by multifactorial logistic regression analysis. A nomogram prediction model was constructed based on this multifactorial logistic regression analysis and the model performance was evaluated using the receiver operating characteristic(ROC)curve. Results:Among the CTD patients,52(35.4%) were included in the CTD-PAH group. The capillary length was longer in the CTD-PAH group than in the CTD-nonPAH group[262.0 (207.0,308.0)vs. 202.0(160.0,272.0),P < 0.05],and the pericapillary score was higher than that in the CTD-nonPAH group[2.40 (0.80,3.92)vs. 1.90(0.40,2.80),P < 0.05]. Logistic regression analysis showed that both long capillary length and high pericapillary score increased the risk of PAH occurrence[OR=1.300(95% CI:1.100-1.500),OR=1.268(95%CI:1.025-1.568)]. The area under the ROC curve of the nomogram prediction model amounted to 0.705(95% CI:0.618-0.792,P < 0.05). Conclusion:The findings suggest that nailfold capillary characteristics,including capillary length and pericapillary score,may serve as independent predictors of PAH in patients with CTD. These results provide a new basis for early screening and individualized therapeutic strategies in CTD-PAH patients.

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周张迪,张译心,戴嘉懿,李东玉,孙晓萱,王嫱.基于甲襞微循环特征的结缔组织病患者肺动脉高压风险评估研究[J].南京医科大学学报(自然科学版),2025,45(9):1276-1285

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  • 收稿日期:2024-11-20
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  • 在线发布日期: 2025-09-11
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