相位对比MRI在评估结缔组织病相关肺动脉高压预后中的应用研究
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1南京医科大学第一附属医院放射科,江苏 南京 210029 ; 2.南京医科大学附属江宁医院医学影像科,江苏 南京 211100 ; 3.南京医科大学附属肿瘤医院(江苏省肿瘤医院)影像中心,江苏省肿瘤防治研究所,江苏 南京 210009

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江苏省自然科学基金(BK20231369)


Research on the application of phase contrast MRI in evaluating the prognosis of CTD⁃PAH
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1Department of Radiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029 ; 2.Departmentof Medical Imaging,the Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing 211100 ; 3.MedicalImage Center,the Affiliated Cancer Hospital of Nanjing Medical University(Jiangsu Cancer Hospital,JiangsuInstitute of Cancer Research),Nanjing 210009 ,China

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    摘要:

    目的:探讨基于相位对比磁共振成像(phase contrast magnetic resonance imaging,PC-MRI)肺动脉血流参数在评估结缔组织病相关肺动脉高压(connective tissue disease-associated pulmonary arterial hypertension,CTD-PAH)患者预后中的应用价值。方法:回顾性分析136例CTD-PAH患者的临床资料及心脏磁共振(cardiac magnetic resonance,CMR)参数,以及基于PC-MRI 测得的主肺动脉(main pulmonary artery,MPA)血流参数。根据随访结果将患者分为发生临床恶化事件组与未发生临床恶化事件组。两组患者的CMR指标差异通过独立样本t检验或Mann-Whitney非参数检验评估。通过Cox比例风险回归筛选终点事件的独立预测因子,依据受试者工作特征(receiver operating characteristic,ROC)曲线最佳阈值进行分组,并采用Kaplan-Meier 生存分析验证其预后差异。结果:与未发生临床恶化事件组相比,发生临床恶化事件组患者的左心室收缩末期容积指数、左心室射血分数、右心室射血分数、左心室心脏指数、主肺动脉峰值流速及主肺动脉平均流速(main pulmonary artery mean velocity, MPAMV)均减低,右心室舒张末期容积指数(right ventricular end-diastolic volume index,RVEDVI)、右心室收缩末期容积指数、 右心室心肌质量指数和心室质量指数均升高,组间差异均有统计学意义(P均 < 0.05)。Cox回归分析表明,MPAMV、RVEDVI 是CTD-PAH患者发生临床恶化事件的独立预测因子。Kaplan-Meier生存分析显示当MPAMV≤6.65 cm/s、RVEDVI≥110.24 mL/m2 时临床恶化事件发生率增加(P均 < 0.001)。结论:RVEDVI与基于PC-MRI序列测得的MPAMV对预测CTD-PAH患者发生临床恶化事件具有重要价值,两指标联合使用可进一步提高预测效能。

    Abstract:

    Objective:To explore the application value of pulmonary blood flow parameters based on phase contrast magnetic resonance imaging(PC - MRI)in assessing the prognosis of patients with connective tissue disease - associated pulmonary arterial hypertension(CTD - PAH). Methods:A retrospective analysis was conducted on the clinical data and cardiac magnetic resonance (CMR)parameters of 136 patients with CTD-PAH,as well as the main pulmonary artery(MPA)blood flow parameters measured by PC -MRI. Based on the follow - up results,patients were divided into two groups:the group with clinical deterioration events and the group without clinical deterioration events. The comparison of CMR indicators between the two groups was conducted using either the independent sample t-test or the Mann-Whitney nonparametric test. Independent predictors of endpoint events were screened by Cox proportional hazards regression. Subsequently,patients were grouped based on the optimal cut-off point of the receiver operating characteristic(ROC)curve,and Kaplan-Meier survival analysis was used to verify the prognostic differences. Results:Compared with the group without clinical deterioration events,patients in the group with clinical deterioration events showed decreased left ventricular stroke volume index,left ventricular ejection fraction,right ventricular ejection fraction,left ventricular cardiac index,main pulmonary artery peak velocity,main pulmonary artery mean velocity(MPAMV). Additionally,they exhibited increased right ventricular end - diastolic volume index(RVEDVI),right ventricular stroke volume index,right ventricular myocardial mass index,and ventricular mass index. These differences were statistically significant(all P < 0.05). Cox regression analysis indicated that the MPA MV and RVEDVI were independent predictors of clinical deterioration events in patients with CTD-PAH. Kaplan-Meier survival analysis showed that the incidence of clinical deterioration events increased when the MPAMV was ≤6.65 cm/s and the RVEDVI was ≥110.24 mL/m(2 all P < 0.001). Conclusion:RVEDVI and MPAMV measured by phase contrast sequences are valuable for predicting clinical deterioration events in CTD-PAH patients. Additionally,using both indicators together can further enhance predictive accuracy.

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许定虎,刘王琰,周清清,徐怡,祝因苏.相位对比MRI在评估结缔组织病相关肺动脉高压预后中的应用研究[J].南京医科大学学报(自然科学版),2025,45(11):1641-1648

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  • 收稿日期:2025-04-14
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  • 在线发布日期: 2025-11-12
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