基于多模态神经调控的音乐疗法改善孤独症谱系障碍儿童共同注意功能的眼动机制
作者:
作者单位:

1南京医科大学附属儿童医院教育处,江苏 南京 210008 ; 2. 南京特殊教育师范学院音乐治疗专业,江苏 南京 210038 ; 3. 南京体育学院运动与脑健康研究院,江苏 南京 210014 ; 4. 扬州大学附属医院康复医学科,江苏 扬州 225000 ; 5. 南京医科大学附属儿童医院康复医学科,江苏 南京 210008

作者简介:

通讯作者:

中图分类号:

基金项目:

南京市卫生科技发展专项基金项目一般性课题(YKK22169)


The oculomotor mechanism of joint attention in children with autism spectrum disorder based on multimodal neuromodulation music therapy
Author:
Affiliation:

1Office of Medical Education, Children's Hospital of Nanjing Medical University, Nanjing 210008 ; 2. Department of Music Therapy, Nanjing Normal University of Special Education, Nanjing 210038 ; 3. School of Sport and Brain Health, Nanjing Sport Institute, Nanjing 210014 ; 4. Department of Rehabilitation Medicine, Affiliated Hospital of Yangzhou University, Yangzhou 225000 ; 5. Department of Rehabilitation Medicine, Children's Hospital of Nanjing Medical University, Nanjing 210008 , China

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:探讨音乐治疗对孤独症谱系障碍(autism spectrum disorder,ASD)儿童共同注意眼动特征的改善效果,为临床干预提供客观依据。方法:采用随机交叉设计,纳入26例3~10岁ASD儿童,随机分为A、B两组,分别接受音乐治疗干预和静坐对照实验,间隔7 d洗脱期后交换实验条件。通过眼动追踪技术记录儿童在共同注意范式任务(眼睛注视、眼睛-头部、眼睛-头-手势三种条件)中的首次注视时间(time to first fixation,TFF),并采用配对样本t检验比较音乐干预效果。结果:音乐治疗后,ASD儿童在所有条件总分的TFF显著短于静坐对照(t=-2.24,P=0.035,Cohen's d=-0.458),眼睛-头-手势条件下的TFF显著短于静坐对照(t=-2.32,P=0.030,Cohen's d=-0.485),仅眼睛注视和眼睛-头部条件下虽差异无统计学意义,但TFF均值短于对照条件。结论:音乐治疗可显著缩短ASD儿童对共同注意目标的首次注视时间,提示其可能通过优化神经信息处理效率改善社交核心缺陷。眼动特征可作为评估音乐治疗疗效的客观指标。

    Abstract:

    Objective: To investigate the effect of music therapy on eye movement characteristics of joint attention (JA) in children with autism spectrum disorder (ASD), providing an objective basis for clinical intervention. Methods: A randomized crossover design was employed. Twenty-six ASD children aged 3-10 years were enrolled and randomly assigned to group A or B. They first received either a music therapy intervention or a quiet-sitting control condition, and after a 7-day washout period, crossed over to the alternate condition. Eye-tracking technology was used to record the time to first fixation (TFF) during a joint attention paradigm task (comprising three conditions: Eye Gaze, Eye-Head, and Eye-Head-Gesture). Paired sample t-tests were applied to compare the effects of the music intervention. Results: Following music therapy, the TFF for the total score across all conditions was significantly shorter compared to the quiet-sitting control condition (t=-2.24, P=0.035, Cohen's d=-0.458). Specifically, the TFF in the Eye-Head-Gesture condition was significantly shorter than in the control condition (t=-2.32, P=0.030, Cohen's d=-0.485). Although the TFF in the Eye Gaze and Eye-Head conditions alone showed no statistically significant difference, the mean TFF was shorter than in the control condition. Conclusion: Music therapy can significantly shorten the time to first fixation on joint attention targets in children with ASD, suggesting that it may improve core social deficits by enhancing neural information processing efficiency. Eye movement characteristics may serve as an objective indicator for evaluating the efficacy of music therapy.

    参考文献
    相似文献
    引证文献
引用本文

张玲,杨畅,史一凡,刘智妹,张洪梅,孙耀金,狄思雨,陈爱国,高夫宁.基于多模态神经调控的音乐疗法改善孤独症谱系障碍儿童共同注意功能的眼动机制[J].南京医科大学学报(自然科学版),2026,(7):999-1010

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2025-10-10
  • 最后修改日期:2025-12-14
  • 录用日期:
  • 在线发布日期: 2026-07-15
  • 出版日期:
关闭