Objective: To explore the application value of a multidisciplinary collaborative model based on the enhanced recovery after surgery(ERAS)concept in the management of patients with diabetic neurogenic bladder(DNB). Methods: This was a prospective randomized controlled trial. Ninety DNB patients were randomly assigned to a control group and an experimental group, with 45 cases in each group. The control group received routine management, while the experimental group received the ERAS multidisciplinary model. The primary outcomes were blood glucose levels [glycated hemoglobin(HbA1c), fasting plasma glucose(FPG), and 2-hour postprandial glucose(2hPG)] and urodynamic parameters [residual urine volume(RUV), maximum flow rate(Qmax), maximum detrusor pressure(Pdetmax), and maximum cystometric capacity(VMCC)] measured before treatment and at 3 and 6 months after treatment. Secondary outcomes included length of hospital stay and hospital costs, scores on the American Urological Association Symptom Index(AUA-SI), Patient Health Questionnaire-9(PHQ-9), and Short Form Qualiveen(SF-Qualiveen), and DNB-related complications(urinary tract infection, urolithiasis, hydronephrosis). Repeated measures analysis of variance(ANOVA)and generalized estimating equations(GEE)were used to evaluate the management effects. Results: Repeated measures ANOVA showed that, except for the interaction effect of FPG(P>0.05, with a significant time effect), the time, group, and interaction effects for 2hPG, urodynamic parameters, and AUA-SI and SF-Qualiveen scores were all statistically significant(P < 0.05); the time and interaction effects for HbA1c and PHQ-9 scores were also statistically significant(P<0.05). GEE analysis revealed that for urinary tract infection, both time and group effects were significant(P < 0.05); for urolithiasis and hydronephrosis, the time effects were significant(P < 0.05). The length of hospital stay and hospital costs in the experimental group were significantly lower than those in the control group(P<0.05). Conclusion: The ERAS multidisciplinary model can improve glycemic control, bladder function, and quality of life in DNB patients, reduce length of hospital stay and medical costs, and has a positive effect on reducing certain complications