Objective: To investigate the trends and characteristics of hepatitis B virus (HBV) epidemiology in Jiangsu, and to provide scientific evidence for the plan of eliminating HBV related threats on public health. Methods: An epidemiological analysis was performed on HBV age-standardized incidence rate (HBV-ASIR) from Jiangsu Province between 2010 and 2024. We mapped spatial characteristics by SaTScan 9.5 and ArcMap 10.2, performed trend testing by Joinpoint regression analysis, predicted short-term future epidemic trends by seasonal autoregressive integrated moving average (ARIMA) model, and evaluated the age, period, and birth cohort effects by age-period-cohort model on HBV-ASIR. Results: The reported HBV-ASIR increased yearly from 16.03 per 100 000 in 2010 to 23.57 per 100 000 in 2024, with an average annual growth rate of 2.79%. The areas with high HBV-ASIR included Taizhou, Huai' an, Suqian, and Xuzhou in Jiangsu. HBV-ASIR exhibited spatiotemporal clustering. A primary cluster was identified in northern Huai ' an and the entire Suqian from August 2012 to February 2017. A secondary cluster was mainly concentrated in northern Xuzhou from January to December in 2020. Male HBV-ASIR predominated with an average male/female ratio of 1.95:1. The HBV-ASIR decreased from 11.75 per 100 000 in 2010 to 6.16 per 100 000 in 2024 in the age group of less than 30 years, with an average annual decrease rate of 4.51%. While, an increasing trend was observed in the age group of more than 30 years, the highest increasing percentage (9.21%)was observed in the age group of more than 70 years. For occupations, peasant workers accounted for the biggest proportion of HBV cases. The optimal model of HBV-ASIR was ARIMA (1, 1, 1)(0, 1, 1)₁₂, predicting that the HBV report incidence would fluctuate stably in 2025-2027. For age-period-cohort model, age effect indicated that HBV-ASIR risk was lower in the age groups less than 25 years(RR<1) than in the reference age group of 30-34(RR=1), while the risk was higher in the age groups more than 50 years (except for 55-59)(RR>1)than in the reference age group. Compared with reference period of 2010-2014 for period effect(RR=1), HBV-ASIR risk increased following the period advancing (RR>1). With the 1925- 1929 birth cohort as the reference (RR=1), the cohort effects revealed that the highest HBV-ASIR risk was among the birth cohort in 1980- 1984. After 1985, HBV-ASIR risk declined rapidly(RR>1), while for those born between 1930 and 1979,the HBV-ASIR risk showed increasing trend year-by-year(RR>1). Conclusion: HBV remains a major public health threat in Jiangsu, and measures based on the epidemiological features are urgently needed, especiallyin a population aged more than 30 years.