Objective: To explore the clinical value of joint indicators based on nutrition-immunity-inflammation [controlling nutritional status(CONUT) score, Naples prognostic score(NPS), modified Glasgow prognostic score(mGPS), global immune-nutrition-inflammation index (GINI), systemic inflammatory response index (SIRI), and C-reactive protein-albumin-lymphocyte (CALLY) index] for the prognosis of glioma patients. Methods: A retrospective analysis was conducted on the medical records of 151 patients with glioma admitted to three comprehensive hospitals in Yibin from 2015 to 2020. The clinical outcomes of outpatient were followed up until December 30, 2024 by telephone or outpatient service. Receiver operating characteristic (ROC) curves were plotted for calculating the area under the curve(AUC) and optimal cutoff values of each indicator. Kaplan-Meier method was used to plot survival curves, Log-rank test and Cox regression analysis were used to identify influencing factors of survival outcomes. Results: The median survival time was 13(9,19) months, and the mortality rate during follow-up was 70.2%(106/151). The 6-month and 1-year survival rates (95% CI) of patients were 88.1%(83.6%–93.8% ) and 53.6%(45.6%–61.7% ), respectively. The optimal cut-off values of CONUT, GINI, SIRI, and CALLY index for predicting patients’ prognosis were 2.5, 1 350, 1.16, and 0.667, respectively, with corresponding AUC values of 0.960, 0.948, 0.883, and 0.979, respectively. Ten factors, including WHO grading, surgical approach, preoperative KPS score, body mass index (BMI), CONUT, NPS, mGPS, GINI, SIRI, and CALLY index, were influencing factors for patients’ prognosis(P < 0.05). CONUT, NPS, CALLY index, and WHO grading were associated with the prognosis of glioma patients, with hazard ratio(HR) values of 0.228, 0.401, 3.012, 3.653(grade Ⅲ), and 5.623(grade Ⅳ), respectively. The one-year survival rates of glioma patients with CONUT ≥ 3 and <3 were 26.1% and 92.1%, respectively. The one-year survival rates of patients with NPS ≤2 and >2 were 89.5% and 31.9%, respectively. The one-year survival rates of glioma patients with CALLY index≥0.667 and <0.667 were 89.5% and 31.9%, respectively. The one-year survival rates of WHO grade Ⅱ, Ⅲ, and Ⅳ patients were 90.2%, 55.2%, and 16.3%, respectively. Conclusion: Patients with glioma have poor prognosis, and CONUT, NPS, CALLY index, and WHO grading may be important predictors of patient prognosis.