Objective： To investigate the relationship of serum neutrophil gelatinase-associated lipocalin(NGAL) and neutrophil-lymphocyteratio(NLR)and evaluate the predictive value of serum NGAL combined with NLR in metabolic syndrome(MS)． Methods： A total of 120 subjects were divided into non-MS group(n=60)and MS group(n=60) respectively. A 75 g OGTT and insulin releasing test were performed． Mean-while, blood lipid, serum NGAL, NLR and other items were measured． Results： The serum NGAL was higher in MS group than in non-MS group (P<0.01). Correlation analysis showed that serum NGAL concentration was positively correlated with BMI, WC, WHR, SBP, DBP, FPG, 2hPG, HbA1c, TG, HOMA-IR and NLR, but negatively correlated with HDL-C and HOMA-β(P＜0.05 or P＜0.01)． With increasing level of NGAL and NLR, the onset risk of MS was rising(P＜0.05). The AUC of NGAL combined with NLR in receiver operating characteristic curve(ROC) analysis for MS was significantly greater than that of NGAL or NLR alone． Conclusion： Serum NGAL concentration was positively correlated with NLR in MS patients. NGAL combined with NLR might be superior marker for predicting MS compared with NGAL or NLR alone．