Objective: To evaluate the effect of sugammadex on hemodynamic parameters and postoperative recovery in patients with atrial fibrillation (AF) during extubation of noncardiac surgery. Methods: A total of 100 patients with AF who received elective non-cardiac surgery in our hospital from June 2017 to December 2019 were selected. All patients were randomly grouped according to the use of sugammadex (group S, n=50) or with no neuromuscular blockade reversals (group C, n=50). We recorded the time to extubation, blood pressure (BP) and heart rate (HR) before extubation and 1, 5, and 10 min after extubation. The complications after extubation, duration of postanaesthesic care unit (PACU) stay and postoperative hospital stay were analyzed as well. Results: Sugammadex showed an advantage in shortening the time to extubation (P<0.05). There was a significant increase of blood pressure at 1, 5 and 10 min after extubation in group C compared with those in group S, and similarly, heart rate was significantly higher in group C compared with those in group S (P<0.05). The incidence of hypoxemia and tachyarrhythmia after extubation in group S was significantly lower than that in group C (P<0.05). However, the duration of postoperative stay were similar in the two groups (P>0.05). Conclusion: Sugammadex alleviated the hemodynamic changes in patients with atrial fibrillation during extubation of noncardiac surgery. It can reverse the neuromuscular block efficiently and safely, reduce the incidence of complications after extubation.