Abstract:Objective:The aim of this study was to explore whether pretreatment Epstein-Barr virus DNA (EBV DNA) status may influence prognosis in newly diagnosed Hodgkin lymphoma (HL) patients. Methods:We retrospectively analyzed 82 HL patients diagnosed between January 2013 and November 2019 in the First Affiliated Hospital of Nanjing Medical University. Results:Among 82 enrolled HL patients, the median age was 32 years (range, 12-79). With a median follow-up of 25 months (4-84 months), the 2-year progression-free survival (PFS) and overall survival (OS) rate was 68.4% and 93.0%, respectively. 12.2% (10/82) patients had positive EBV DNA status and the median viral load of them was 8.66×10^3 copies/mL (range, 5.21×10^3-5.35×10^4copies/mL). Those with positive EBV DNA status had inferior PFS (P=0.003) as well as OS (P<0.001). Baseline EBV DNA status was observed as an independent prognostic factor in OS (hazard ratio 7.238, 95% CI 1.252-41.851, P=0.027) on multivariate Cox analysis while a trend to predict PFS (hazard ratio 2.567, 95% CI 0.989-7.162, P=0.056). Conclusion:Our data demonstrated that pertreatment EBV DNA status can be an optimal biomaker to reflect HL patients prognosis.