Objective：To evaluate the safety and efficiency of the percutaneous left atrial appendage occlusion (LAAO) in nonvalvular atrial fibrillation (NVAF) patients with coronary heart disease (CAD). Methods：51 NVAF patients were consecutively accepted LAAO between June 2015 and July 2017. Patients were divided in two groups: 15 with CAD and 36 without CAD. All patients were followed up after discharge with transesophageal echocardiography (TEE) examination. Results：Among these 51 patients, there were no hemorrhagic stroke or major bleeding. The incidence of end-point events had no statistical difference between CAD and non-CAD. Compared with CAD patients who accepted long-term antithrombotic medication, there was no obvious difference in stroke rate and mortality in CAD accepted LAAO group, whereas a further reduction of hemorrhage (n=5/20% vs. n=0, P=0.031) was shown. A significant correlation (P<0.001, r=0.580) was detected between moderate or severe left atrial spontaneous echo contrast (LASEC) and the composite end point events. Conclusion：There are similar safety and effectiveness for LAAO procedure in NVAF patients with CAD and without CAD. Meanwhile, LASEC is a predictive factor of LAAO in NVAF patients combined CAD.