Objective: To understand the infection situation of coxsackievirus A6 (CV-A6) and the duration of detoxification, and guide and formulate prevention and control strategies and measures scientifically. Methods: The case definition was conductecx and the case search was carried out. After informed consent proving, all the cases were collected and the children's throat swab and anal swab specimens from small class 1 and middle class 2 with higher attack rates were obtained. We used the RT-PCR to carry out intestinal virus nucleic acid detection as well. For children who tested positive, collecting specimens for detection once every two weeks again, the collections would stop if two consecutive tests were negative. Results: The attack rate of children was 8.2% (17/208), and 17 cases of covert infection were found. The epidemic curves of small class 1 and middle class 2 showed unimodal distribution. The transmission of diet and drinking water was excluded after conducting the hygienic investigation. Pathogen detection showed the positive CV-A6 enterovirus nucleic acid. The proportion of covert infection was 52% (95%CI: 34% ~ 69%) in tested positive patients. The median duration of detoxification was 18 days (95% CI: 16 days ~ 25 days), the shortest is one week (4 days), and the longest was up to 5.5 weeks (39 days). Additionally, the Log-rank test showed no statistical significance (P > 0.05) between cases and covert infectors, male and female, the different duration of detoxification of pharyngeal and intestinal. Conclusion: The proportion of CV-A6 covert infection was high, and the duration of detoxification was long in this outbreak. In such contexts, it is suggested to increase surveillance sensitivity. After the cases finished the quarantine and return to the school, continuous health monitoring and prevention and control measures should also be carried out.