Objective: To evaluate the short-term efficacy and safety of interventional occlusion in the treatment of patent foramen ovale. Methods: This retrospective study enrolled 116 migraine or cryptogenic stroke patients from Department of neurology, the first affiliated hospital of Nanjing medical university from February 2019 to January 2021, in which level III ~ IV right-to-left shunt was screened out by contrast-enhanced transcranial doppler. These patients were finally diagnosed with patent foramen ovale and received interventional closure in Department of cardiovascular. We carried out regular follow-up of post-closure by clinics and telephones. Results: The success rate of closure was 97.4%. During the follow-up period, there were no severe complications such as occluder displacement, pericardial effusion and new arrhythmia. Transcranial doppler confirmed that the right-to-left shunt volume of 75.2% (85/113) patients decreased after surgery. The HIT-6 scores of migraine patients at 6 months after surgery were significantly lower than those before surgery (P < 0.001), and there was no new stroke in the follow-up period. Conclusion: Recent follow-up shows that the closure of patent foramen ovale is an effective and safe therapy for patent foramen ovale patients with migraine and cryptogenic stroke.