Abstract:Objective To explore the relationship between the left atrial appendage morphology and the area of the left atrial appendage orifice and ischemic stroke via CT, hoping to provide a kind of non-invasive and effective risk factors for ischemic stroke. Methods Sixty non-valvular atrial fibrillation patients (stroke group) with ischemic stroke admitted to Southeast University Hospital from April 2020 to April 2021 were continuously selected. The control group included 60 age-matched patients with nonvalvular atrial fibrillation without a history of stroke. All patients underwent transthoracic echocardiography (TTE), transesophageal echocardiography (TEE) and computed tomography angiography (Computed tomography angiography, CTA) examinations. After the CTA inspection is completed, the original image is obtained and the area of the left atrial appendage orifice is measured; the left atrial appendage is obtained by three-dimensional reconstruction using GE's AW4.61 workstation. According to the left atrial appendage morphology, it is divided into chicken wing type and non-chicken wing type, and the left atrial appendage morphology, The relationship between the area of the left atrial appendage orifice and ischemic stroke. Results The clinical data found that the proportion of persistent atrial fibrillation in the stroke group was significantly higher than that in the control group, and the CHA2DS2-VASc score before stroke was significantly higher; compared with the control group (50.8±15.4, cm/s), the stroke group ( The LAAFV of 32.0±12.4, cm/s) was significantly reduced (P<0.001); compared with the control group, the proportion of non-chicken wing left atrial appendages in the stroke group was significantly increased (P<0.001), and the inner diameter of the left atrium and the area of the left atrial appendage were obvious Increase (P<0.001); compared with the control group, the left atrial appendage volume of the stroke group was not found to be statistically significant; the statistically significant variables were included in the multiple linear regression analysis, and the multiple linear regression analysis showed that the non-chicken wing type left atrial appendage Atrial appendage morphology, left atrial appendage foramen area, left atrial diameter, pre-stroke score, and LAAFV are independent predictors of ischemic stroke. Conclusion In patients with non-valvular atrial fibrillation, atrial fibrillation type, left atrial appendage morphology, left atrial appendage foramen area, pre-stroke CHA2DS2-VASc score, left atrial diameter, LAAFV and ischemic stroke are closely related, non-chicken wing type left atrial appendage, more large left atrial appendage foramen and left atrial diameter are independent predictors of ischemic stroke in patients with non-valvular atrial fibrillation. Key words atrial fibrillation; left atrial appendage morphology; left atrial appendage foramen area; ischemic stroke