Advanced pancreatic cancer has a poor prognosis and a short survival, and is usually can not treated by surgery.The efficacy of radiotherapy and chemotherapy alone in advanced pancreatic cancer is limited, and the overall survival time of patients is poor.Therefore, the exploration of ablation therapy for advanced pancreatic cancer has been a research hot spot in recent years.These include radio-frequency ablation (RFA), cryoablation, irreversible electroporation (IRE), high intensity focused ultrasound (HIFU) and many other methods.Moreover, ablation combined with chemoradiotherapy and immunotherapy can form a comprehensive treatment strategy for patients with advanced pancreatic cancer, often achieving the purpose of effectively improving the survival of patients.This article reviews the current status of comprehensive treatment strategies for advanced pancreatic cancer after ablation therapy.