Abstract: Objective To evaluate the prevention and treatment effect of Qingshu ointment on radiation-induced skin injuries (RISI). Methods: A total of 98 patients with esophageal cancer treated with irradiotherapy were randomly assigned into study group and control group from June 2017 to June 2019. The study group applied Compound Qingshu Ointment on the skin of the irradiated area before the start of radiotherapy, once a day, until 2 weeks after the end of the radiotherapy; the control group did not perform special treatment on the skin in the radiation field. Results ①The incidence of acute radiation skin injury in both groups was 100% when irradiated with 40Gy, and neither group had grade III skin injury; after 50Gy irradiation, the incidence of acute radiation skin injury at grade II and above in the control group was 44.7%, and the study group 29.4%, no significant statistical difference (P>0.05); at the end of the irradiation, the incidence of severe (level III) acute radiation skin injury in the study group and control group were 2.0% and 19.1% (p<0.05), respectively; ②Neck In patients with cervical lesions, the incidence of grade III acute radiation skin injury is significantly higher than that of the middle and lower thoracic patients due to high-dose irradiation on the neck. ③ There was no adverse reaction in the two groups. Conclusion Compound Qingshu Ointment can significantly reduce the severity of radiation-induced skin damage and delay the occurrence of radiation-induced skin damage. At the same time, the drug has good safety.