Health research project for cadres in Jiangsu Province
[摘 要] 目的：老年冠心病患者生存影响因素的观察分析。方法：收集140例老年冠心病患者的相关资料，平均随访3.5年。探讨患者发生主要不良心脑血管事件(major adverse cardiac and cerebral events, MACCE)的影响因素，进一步分析各影响因素对MACCE的预测价值。结果：根据MACCE组与无MACCE组临床资料比较、Cox回归分析及Kaplan-Meier曲线结果，尿素氮（blood urea nitrogen, BUN）、总胆固醇(total cholesterol, TC)、左房内径（left atrial diameter, LAD）、心脏瓣膜钙化(cardiac valve calcification, CVC)是老年冠心病患者MACCE发生的相关影响因素。本研究未发现25羟维生素D水平与MACCE的发生相关。根据受试者工作特征( receiver operating characteristic, ROC)曲线结果，联合BUN、TC、LAD、CVC预测MACCE的价值最大。结论：本研究发现老年冠心病患者BUN、TC、LAD、CVC是MACCE发生的重要影响因素，而未发现25羟维生素D水平与MACCE的发生相关。
[Abstract] Objective:To observe and analyze the factors affecting the survival of elderly patients with coronary heart disease. Methods: Datas of 140 elderly patients with coronary heart disease were collected and patients were followed up for an average of 3.5 years. The influencing factors of major adverse cardiac and cerebral events (MACCE) in patients were investigated, and the predictive value of each influencing factor for MACCE was further analyzed. Results:According to the comparison of clinical datas between MACCE group and non-MACCE group, Cox regression analysis and Kaplan-Meier curve, blood urea nitrogen (BUN), total cholesterol (TC), left atrial diameter (LAD), and cardiac valve calcification(CVC) were associated with the development of MACCE in elderly patients with coronary heart disease. There was no correlation between 25 hydroxyvitamin D level and the occurrence of MACCE.According to the results of receiver operating characteristic (ROC) curve, the combination of BUN, TC, LAD and CVC had the greatest value in predicting MACCE.Conclusion:In this study, BUN, TC, LAD and CVC are found to be important influencing factors for the occurrence of MACCE in elderly patients with coronary heart disease, while there is no correlation between the level of 25 hydroxyvitamin D and the occurrence of MACCE.