Abstract：Objective To evaluate the reliability of Salivary gland Young's modulus in the diagnosis of Sjogren's syndrome. Methods To observe the Young's modulus of the salivary glands of the parotid, submandibular, and sublingual glands in 45 SS patients and 51 healthy volunteers. T-test evaluates the difference in Young's modulus values between the bilateral salivary glands and the two groups. The internal correlation coefficient evaluates the internal consistency of physicians, the Bland-Altman scatter plot analyzes the consistency between physicians. Spearman or person correlation analysis was used to observe the effects of gender, age, height, weight and gland thickness. Results There was no significant difference of the salivary glands Young's modulus on both sides, P>0.05. There was a significant difference of the salivary glands Young's modulus between the two groups, P<0.05. Regardless of the SS group and the healthy group, there had good agreement of the salivary gland Young's modulus in inter-physicians and intra-physicians. The ICC was 0.751 to 0.933, and the difference between the average values was 96.43% to 99.02% within the consistency limit and 95% confidence. The salivary gland Young's modulus is not affected by gender, age, height, weight and gland thickness. Conclusion Regardless of SS patients or healthy volunteers, the salivary gland Young's modulus is not affected by the examiner and the subject's own factors, and has good reliability.