目的: 评价涎腺杨氏模量值在干燥综合征诊断中的可靠性。方法: 观察45例SS患者及51例健康志愿者腮腺、颌下腺、舌下腺的涎腺杨氏模量值,运用t检验评价双侧涎腺杨氏模量值差异；组内相关系数评价医师内部一致性,Bland-Altman 散点图分析医师间的一致性；Spearman或Person相关分析观察受试者性别、年龄、身高、体重及腺体厚度的影响。结果: 无论SS组与健康组,双侧涎腺杨氏模量值均无明显差异,P＞0.05；两组之间存在显著差异,P＜0.05；医师内部及医师间测量的涎腺杨氏模量值均具有良好的一致性,ICC为0.751~0.933,平均值的差值有96.43%~99.02%在一致性界限及其95%置信区间以内。杨氏模量值不受性别、年龄、身高、体重及腺体厚度影响。结论: 无论SS患者或健康志愿者,涎腺杨氏模量值均不受检查医师和受检者自身因素影响,具有良好的可靠性。
Abstract：Objective To evaluate the reliability of Salivary gland Young's modulus in the diagnosis of Sjogren's syndrome. Methods To observe the Young's modulus of the salivary glands of the parotid, submandibular, and sublingual glands in 45 SS patients and 51 healthy volunteers. T-test evaluates the difference in Young's modulus values between the bilateral salivary glands and the two groups. The internal correlation coefficient evaluates the internal consistency of physicians, the Bland-Altman scatter plot analyzes the consistency between physicians. Spearman or person correlation analysis was used to observe the effects of gender, age, height, weight and gland thickness. Results There was no significant difference of the salivary glands Young's modulus on both sides, P>0.05. There was a significant difference of the salivary glands Young's modulus between the two groups, P<0.05. Regardless of the SS group and the healthy group, there had good agreement of the salivary gland Young's modulus in inter-physicians and intra-physicians. The ICC was 0.751 to 0.933, and the difference between the average values was 96.43% to 99.02% within the consistency limit and 95% confidence. The salivary gland Young's modulus is not affected by gender, age, height, weight and gland thickness. Conclusion Regardless of SS patients or healthy volunteers, the salivary gland Young's modulus is not affected by the examiner and the subject's own factors, and has good reliability.