The Affiliated Sir Run Run Hospital of Nanjing Medical University
目的：了解我院健康体检教师人群中甲状腺结节的检出率及影响因素。方法：回顾分析2018年10月-2021年6月期间在我院健康教师体检人群检查项目（包括性别，年龄，职业，身高，体重等），实验室检查（空腹血糖，血脂，肝功能，尿酸，C13呼气检测等）及甲状腺彩超检查。应用Logistic多因素回归分析甲状腺结节的影响因素。结果：1.全部6096例体检者中，检查发现甲状腺结节2539例，总检出率为41.65%，其中男性38.20%，女性43.03%；单发结节1340例（21.98%），多发结节1199例（19.67%）；对于甲状腺结节根据TI-RADS分级，结果表明3级最多，占22.74%；年龄越大检出率越高，各年龄组内存在较大的差异（P<0.05）；此外甲状腺结节检出部位分别是双侧叶(17.27%)＞右侧叶(13.27%)＞左侧叶(10.89%)＞甲状腺峡部(0.21%)；2. 女性教师人群以中教组检出率最高（49.44%），其中30岁以下和30-39岁两个年龄组内不同教师类型检出率具有统计学差异（P<0.05）3.和非甲状腺结节组相比，高血压、空腹血糖异常，高脂血症、超重、肥胖发生率较高，两组有统计学差异（P<0.05） ；4. 经Logistic多因素回归分析显示，女性是甲状腺结节发病的独立危险因素（OR=1.913，P<0.05），与小于30岁相比，40-49岁、50-59岁、≥60岁教师的甲状腺结节发病风险较高（OR=1.402、2.923、4.637，均P<0.05），而与幼教组相比，高校教师的甲状腺结节发病风险较低（OR=0.718，P<0.05）。结论：本院健康体检的教师人群中甲状腺结节的检出率虽然偏高，但恶性度不高，超重肥胖、“三高”和甲状腺结节密切相关，女性、年龄，中学教师是甲状腺结节的危险因素，需综合关注上述指标，提高健康管理意识。
To investigate the detection rate and influencing factors of thyroid nodules among healthy teachers in our hospital. Methods: To retrospectively analyze the examination items (including gender, age, occupation, height, weight, etc.), laboratory examination (fasting blood glucose, blood lipids, liver function, uric acid, C13 breath test, etc.) and thyroid ultrasonography were retrospectively analyzed in the health teacher physical examination population of our hospital from October 2018 to June 2021. Logistic multifactor regression was used to analyze the influencing factors of thyroid nodules. Results: 1. Thyroid nodules were found in 2539 of 6096 patients, with a total detection rate of 41.65%, including 38.20% male and 43.03% female. There were 1340 single nodules (21.98%) and 1199 multiple nodules (19.67%). For thyroid nodule classification according to Ti-RADS, grade 3 was the most, accounting for 22.74%. The older the age, the higher the detection rate was, and there were significant differences among different age groups (P<0.05). In addition, thyroid nodules were detected in bilateral lobe (17.27%) > right lobe (13.27%) > left lobe (10.89%) > thyroid isthmus (0.21%). 2. The detection rate of female teachers in middle education group was the highest (49.44%), and the detection rate of different types of teachers in the two age groups of 30 years old and 30-39 years old had statistical difference (P<0.05) 3. Compared with the non-thyroid nodule group, the incidence of hypertension, abnormal fasting glucose, hyperlipidemia, overweight and obesity was higher in the two groups, and the difference was statistically significant (P<0.05). 4. Logistic multifactor regression analysis showed that female was an independent risk factor for thyroid nodules (OR=1.913, P<0.05), and teachers aged 40-49, 50-59 and ≥60 had a higher risk of thyroid nodules than those aged less than 30 (OR=1.402, 2.923, 4.637, All P<0.05), and compared with preschool education group, college teachers had a lower risk of thyroid nodules (OR=0.718, P<0.05). Conclusion: In our hospital, the detection rate of thyroid nodules among teachers who underwent physical examination is high, but the malignancy is not high. Overweight, obesity and "three high" are closely related to thyroid nodules. Female, age and middle school teachers are risk factors for thyroid nodules, so comprehensive attention should be paid to the above indicators to improve health management awareness.