肌腱蛋白C对支气管肺发育不良诊断价值的前瞻性研究
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南京医科大学附属淮安第一医院

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江苏省卫生健康委妇幼重点课题(F201909);江苏省卫健委重点项目(ZDB2020005)


Prospective study on the diagnostic value of tenascin C in bronchopulmonary dysplasia
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the Affiliated Huaian First People’s Hospital of Nanjing Medical University

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Jiangsu Provincial Health Commission Key Project for Women and Children(F201909);Key Project of Jiangsu Provincial Health Commission(ZDB2020005)

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    摘要:

    目的 探讨血清肌腱蛋白C(Tenascin C,TNC)对早产儿支气管肺发育不良(Bronchopulmonary dysplasia,BPD)的诊断价值。方法 选择2018-2020年南京医科大学附属淮安第一医院新生儿科79例极低出生体重早产儿,根据2018 NICHD诊断标准分为非BPD组(n = 48)和BPD组(n = 31):(1)ELISA法检测血清TNC水平;(2)多因素Logistic回归分析BPD发生的独立危险因素;(3)分析血清TNC水平与BPD严重程度的相关性;(4)制作TNC诊断BPD的受试者工作特征曲线。结果 1.早产儿血清TNC水平,非BPD组(95.03±19.73ng/ml)与BPD组(125.40±19.34ng/ml)间差异有统计学意义(P<0.001),不同级别BPD组间差异有统计学意义(P<0.001)。2.早产儿发生BPD的独立危险因素包括吸入高浓度氧、吸氧时间及血清TNC水平(P<0.05)。3.血清TNC水平与BPD严重程度呈正相关(r =0.7031,P<0.0001)。4.血清TNC诊断BPD的曲线下面积为0.8807(P<0.0001),敏感度为96.8%,特异度为66.7%。结论 血清TNC水平在BPD中增高,诊断的灵敏度及特异度较高,可作为早产儿BPD判断的标志物之一。

    Abstract:

    Objective To explore the diagnostic value of serum Tenascin C (TNC) in Bronchopulmonary dysplasia (BPD) of the premature infants. Methods Seventy-nine very low birth weight premature infants were enrolled from the Department of Neonatology, the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University from 2018 to 2020. According to the 2018 NICHD diagnostic criteria, they were divided into non-BPD group (n = 48) and BPD group (n = 31): (1) ELISA was used to detect serum TNC level; (2) Multivariate Logistic regression analysis of independent risk factors for BPD was conducted; (3) The correlation between serum TNC level and the severity of BPD was analyzed; (4) Receiver Operating characteristic curve (ROC) of TNC for diagnosis of BPD was made. Results 1. The serum TNC level of preterm infants was statistically different between the non-BPD group (95.03±19.73ng/ml) and the BPD group (125.40±19.34ng/ml) (P < 0.001), and there was statistical difference between different levels of BPD groups (P < 0.001). 2. The independent risk factors for BPD in premature infants included inhalation of high concentrations of oxygen, oxygen duration and serum TNC level (P < 0.05). 3. Serum TNC level was positively correlated with the severity of BPD (r =0.7031, P < 0.0001). 4. The area under the curve for the diagnosis of BPD by serum TNC was 0.8807 (P < 0.0001), the sensitivity was 96.8%, and the specificity was 66.7%. Conclusion Serum TNC level increases in BPD, and the diagnostic sensitivity and specificity is high, which can be used as one of the biomarkers for the diagnosis of premature BPD.

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  • 收稿日期:2022-03-21
  • 最后修改日期:2022-09-28
  • 录用日期:2023-04-17
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