【Abstract】Objective: Evaluate the intervention effect of sequential nutrition therapy for patients with Neurogenic Bowel Dysfunction (NBD). Methods: Selected one patient with "NBD, irretrievable elsewhere" admitted in September 2021 as the research object. Sequential nutrition therapy combined with bowel function rehabilitation training and bowel management nursing intervention were used to relief the gastrointestinal symptoms. The occurrence of patient`s gastrointestinal reactions, nutrient intake, and nutrition status evaluation (total protein, albumin, hemoglobin) before and after were analyzed. Results: After the intervention, the gastrointestinal dysfunction was significantly improved. The total nutrient intake, as well as the enteral nutrient intake was promoted to meet the patient's target needs. The absorption of nutrients was more reasonable with a more appropriate intake ratio of Carbohydrate, Protein and Fat. However, the nutrition status of the patients was basically the same after this nutrition therapy. The strongest negative correlation appeared between TP and total energy intake, TP and total protein, as well as TP and enteral protein intake (Co1=-0.92, Co2=-0.88, Co3=-0.85). Conclusion: Sequential nutrition therapy can effectively relieve gastrointestinal dysfunction, promote digestive system function, and improve the satisfaction of nutritional needs for adult patients with neurogenic bowel. Its role of improving nutrition status of NBD patients needs to be further explored.