Department of Dental Implantology, The Affiliated Stomatological Hospital of Nanjing Medical University ， Jiangsu Province Key Laboratory of Oral Diseases， Jiangsu Province Engineering Research Center of Stomatological Translational Medicine
目的：探究美学区引导骨再生术后骨替代材料留存率的相关性因素。 方法：收集2019年1月至2021年12月在我院种植科行美学区种植同期行引导骨再生术患者术前、术后即刻及术后六个月的锥形束CT数据共50例。在mimics19.0软件中重建患者上颌的三维模型，配准计算骨替代材料留存率，并将其与其他临床资料进行相关性分析。 结果：术后六个月的骨替代材料留存率与使用浓缩生长因子、骨劈开及患者凝血酶时间存在统计学相关性（P<0.05），且患者凝血酶时间与骨替代材料留存率呈线性负相关（P<0.01）。 结论：进行浓缩生长因子和骨劈开治疗均与术后六个月骨替代材料留存率提高相关，而凝血酶时间与骨替代材料留存率呈线性负相关。
Objective: To investigate the relevant factors of bone substitute materials retention rate after implant surgery with guided bone regeneration in the aesthetic zone. Methods: From January 2019 to December 2021, the cone beam CT data of patients who received implant surgery in the aesthetic zone with guided bone regeneration meanwhile in the implant department of our hospital were collected before the operation, immediately after the operation and six months after the operation. Three-dimensional model reconstruction of the patient's maxilla is performed in mimics19.0, along with registering three reconstructed models and calculating the retention rate of bone substitute materials, and the analysis of its correlation with other clinical data. Results: The retention rate of bone substitute materials in six months after the operation is statistically correlated with the use of concentrated growth factor, alveolar ridge splitting technique and thrombin time (P < 0.05). There is a linear negative correlation between thrombin time and the retention rate of bone substitute materials (P < 0.01). Conclusion: Both CGF and alveolar ridge splitting technique are associated with the increase of bone substitute materials’ retention rate in six months after the implant surgery, while thrombin time is linearly and negatively correlated with bone substitute materials’ retention rate.