Objective: To investigate the relevant factors of bone substitute materials retention rate after implant surgery with guided bone regeneration in the aesthetic zone. Methods: From January 2019 to December 2021, the cone beam CT data of patients who received implant surgery in the aesthetic zone with guided bone regeneration meanwhile in the implant department of our hospital were collected before the operation, immediately after the operation and six months after the operation. Three-dimensional model reconstruction of the patient's maxilla is performed in mimics19.0, along with registering three reconstructed models and calculating the retention rate of bone substitute materials, and the analysis of its correlation with other clinical data. Results: The retention rate of bone substitute materials in six months after the operation is statistically correlated with the use of concentrated growth factor, alveolar ridge splitting technique and thrombin time (P < 0.05). There is a linear negative correlation between thrombin time and the retention rate of bone substitute materials (P < 0.01). Conclusion: Both CGF and alveolar ridge splitting technique are associated with the increase of bone substitute materials’ retention rate in six months after the implant surgery, while thrombin time is linearly and negatively correlated with bone substitute materials’ retention rate.