睡眠障碍与非酒精性脂肪性肝病
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上海中医药大学附属曙光医院

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国家自然科学基金(81774256,81904164,82074336)


Sleep disorders and nonalcoholic fatty liver disease
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    摘要:

    摘要:随着生活方式和膳食结构的改变,非酒精性脂肪性肝病(nonalcoholic fatty liver disease, NAFLD)的全球患病率逐年上升,给医疗卫生系统带来了严重的负担。虽然临床医生对NAFLD病理生理机制的认识不断加深,但有效的治疗手段仍在探索中,生活方式干预仍是众多指南和医生推荐的NAFLD的一线疗法。睡眠是一个复杂的、高度调节的过程,对人类健康至关重要。众多研究表明睡眠障碍与慢性肝病尤其是非酒精性脂肪肝密切相关。然而,关于睡眠障碍如何影响NAFLD尚不明确。因此,本文旨在综述睡眠障碍与NAFLD之间的关系,使NAFLD患者从生活方式上进行改变,这将对NAFLD患者终身受益。

    Abstract:

    With changes in lifestyle and dietary structure, the global prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing year by year, posing a serious burden on health care systems. While clinicians' understanding of the pathophysiological mechanisms of NAFLD continues to improve, effective treatments are still being explored, and lifestyle interventions remain the first-line therapy for NAFLD as recommended by numerous guidelines and physicians. Sleep is a complex, highly regulated process that is critical to human health. There is a growing consensus that sleep disorders are closely associated with chronic liver disease, especially NAFLD. However, it is not clear how sleep disorders affect NAFLD. Therefore, the purpose of this paper is to review the relationship between sleep disorders and NAFLD and to enable NAFLD patients to make lifestyle changes, which will benefit NAFLD patients.

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历史
  • 收稿日期:2022-04-02
  • 最后修改日期:2022-10-06
  • 录用日期:2023-07-09
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