Objective:Prepare temperature/ultrasound dual-responsive lipid phase-change droplets (LPCDs) and combine them with hydrogels to regulate liquid-gas transitions in the core of lipid droplets by temperature or low intensity focused ultrasound (LIFU), and then regulate the structure and mechanical properties of the hydrogels. Methods: Firstly, perfluorohexane (PFH) phase-change droplets of lipid membrane shell were prepared by thin-film hydration method. The morphological changes and phase transition ability under the control of temperature and LIFU were characterized. At the same time, the contrast-enhanced ability of LPCDs before and after liquid-gas phase transition was evaluated. On this basis, it was combined with hydrogels, and the effects of temperature / ultrasound induced droplet transition on the internal structure, buoyancy and mechanical properties of hydrogels were evaluated by characterization.Results: LPCDs had good phase transition ability and contrast-enhanced ultrasound ability under the control of temperature or ultrasound. Lipid droplet phase transitions can cause many micro-pores inside the hydrogel, which significantly improving buoyancy, varying compressive stress and swelling properties. Conclusion: lipid phase change droplet-hydrogel Composite material( LPCDs@Hy ) is a kind of potential intelligent response micro/nano material for diagnosis and treatment.