慢性阻塞性肺疾病生物学标志物的研究进展
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江苏省社会发展项目(BE2020651),江苏省第五期“333” 高层次人才项目(BRA2020015),常州市科技项目(CE20205023), 常州市卫健委青年人才科技项目(WZ202010)


Research Progress on Biomarkers of Chronic Obstructive Pulmonary Disease
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Jiangsu province social development project (BE2020651),Jiangsu province "333 talents" project (BRA2020015),Changzhou Sci & Tech Program (CE20205023),Changzhou Health Commission Young talents Sci & Tech Program(WZ202010)

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    摘要:

    慢性阻塞性肺疾病是以气流受限为主要特征的一种疾病,与吸入香烟、烟雾等有害气体或有害颗粒引起的复杂病理改变有关,包括大、小气道的炎症和肺实质的破坏。COPD的发病机制尚未十分明确,目前认为与气道炎症、免疫因素、氧化应激、蛋白酶及抗蛋白酶失衡等机制有关。与 COPD发病机制密切相关的分子生物学标志物在疾病发生发展过程中发挥着重要作用,本文对不同发病机制对应的分子生物学标志物进行综述。

    Abstract:

    Chronic obstructive pulmonary disease (COPD) is a disease characterized by airflow restriction. It is related to complex pathological changes caused by inhalation of harmful gases or particles such as cigarettes and smoke, including inflammation of large and small airways and destruction of lung parenchyma. The pathogenesis of COPD is still unclear, and is currently believed to be related to airway inflammation, immune factors, oxidative stress, protease and antiprotease imbalance. Molecular biomarkers closely related to the pathogenesis of COPD play an important role in the occurrence and development of the disease. This paper reviewed the molecular biomarkers corresponding to different pathogenesis of COPD.

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  • 收稿日期:2022-04-26
  • 最后修改日期:2022-06-02
  • 录用日期:2023-07-09
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