Stroke is a leading cause of adult disability worldwide, therefore promoting motor functional recovery from stroke is very important. Motor network remodeling is critical for motor functional recovery after stroke. The structural and functional reorganization of the motor network can be assessed by functional magnetic resonance imaging (fMRI), and environmental enrichment (EE), a generally accepted strategy to promote stroke recovery, can be employed to reveal the molecular mechanisms underlying motor network remodeling. This paper reviewed the basal and clinical research progress of neural network remodeling after stroke.