Objective：To analyze the influencing factors of frailty in elderly hospitalized patients. Methods：A total of 264 inpatients aged ≥ 60 years were enrolled in the Division of Geriatric Endocrinology. The frail status of the patients was assessed by the Fried Physiological Frailty Phenotype, and the patients were divided into three groups: non-frailty, pre-frailty and frailty. Clinical data were collected, and clinical indicators such as nutritional index, blood glucose, lipids, renal function, and thyroid function were detected. The differences in muscle mass, muscle function, physical function, nutrition, cognition, psychology, prognosis of the three groups, as well as the correlation of these factors with frailty were analyzed by using geriatric assessment. Results：There were 69 patients in the non-frail group, 149 patients in the pre-frail group, and 46 patients in the frail group. There were no significant differences in age, body mass index (BMI), and waist-to-hip ratio among the three groups of patients. The clinical test results of nutritional indicators including serum transferrin, pre-albumin, albumin and 25-hydroxyvitamin D levels, fasting blood glucose, glycosylated hemoglobin, lipids, uric acid, urea nitrogen and creatinine, thyroid function had no significant differences among the three groups of patients. Compared with the non-frail and pre-frail patients, the inpatients in the frail group had significantly decreased muscle mass, decreased grip strength, and increased 5-time sit-up time; significantly decreased 4-meter walking speed, and also decreased SPPB and ADL scores. The nutritional status of elderly inpatients in the frail group was poor. MMSE assessment showed cognitive decline, and there was no significant difference in MoCA assessment results. Anxiety and depression scores were elevated in the frail group, indicating a significant increase in the occurrence of anxiety and depression. Mortality was also higher among older hospitalized patients in the frail group. High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), FT4, handgrip strength, and nutritional status (MNA score) are factors associated with frailty. Conclusion：The incidence of frailty in elderly hospitalized patients is high and is affected by many factors, Including blood lipids, thyroid function, nutritional status, etc.. In addition to paying attention to the disease itself, it is necessary to pay attention to physical activity, cognitive function, emotional state, etc. in the diagnosis and treatment of elderly patients, so as to provide a basis for reasonable diagnosis and treatment.