代谢组学在多环芳烃诱发儿童哮喘中的应用
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南京医科大学

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国家自然科学基金项目(面上项目,重点项目,重大项目)(82073630)


Application of metabolomics in childhood asthma induced by PAHs
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    摘要:

    多环芳烃是一类广泛存在于环境中的持久性有机污染物。随着中国工业化进程加速,化石燃料的使用增加,多环芳烃在大气中的含量也随之升高。已有报道证明多环芳烃是儿童哮喘发病的潜在危险因素,但其具体致病机制尚未完全阐明。近年来,代谢组学的发展为揭示环境污染物的毒理机制和疾病病因学提供了有力的研究手段。本文将从代谢角度,特别是一碳代谢和色氨酸代谢两个方面综述多环芳烃通过改变表观遗传模式和激活芳烃受体,介导炎症并诱发儿童哮喘的机制。

    Abstract:

    Polycyclic aromatic hydrocarbons (PAHs) are a large group of persistent organic pollutants that widely exist in the environment. The risk of PAHs exposure has increased with the increasing industrialization and fossil fuels consumption in China. It has been reported that PAHs are potential risk factors for asthma in children, but the specific pathogenesis has not been fully clarified. In recent years, the development of metabolomics has provided a promising approach to elucidate the toxicological mechanism of environmental pollutants. In this paper, we will review the mechanism of PAHs mediating inflammation and inducing childhood asthma by changing epigenetic patterns and activating aromatic hydrocarbon receptor signaling pathway from the perspective of metabolism, especially one carbon metabolism and tryptophan metabolism.

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  • 收稿日期:2022-10-19
  • 最后修改日期:2023-02-24
  • 录用日期:2023-07-09
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