血管周围脂肪与心血管疾病研究进展
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1.南京医科大学第一附属医院内分泌科;2.南京医科大学第一附属医院内分泌科,江苏 南京 210029;3.南京医科大学第一附属医院

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江苏省卫生健康委员会“甲状腺功能衰退与老年肌少症的关系研究” [BJ20013]


Research progress of perivascular adipose tissue and cardiovascular disease
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Endocrine Department of the First Affiliated Hospital of Nanjing Medical University

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    摘要:

    在人体中,存在着一种围绕着除脑血管外的所有心血管的脂肪组织,称为血管周围脂肪(perivascular adipose tissue,PVAT)。近年来,由于其位置及功能的特殊性,其被视为一种不同于传统内脏脂肪的新型脂肪组织,其可通过旁分泌、内分泌具有促进血管舒缩功能的脂肪因子,介导免疫炎症反应及脂肪细胞表型转换等途径,对心血管系统产生双面性的影响,包括在生理状态下对心血管的保护作用及病理状态下促心血管疾病发生的不良作用。而通过对PVAT的实验室及影像学检查与干预,有助于我们提高对心血管疾病的诊断能力、增加具有可行性的治疗手段。本文将叙述PVAT与经典脂肪类型的区别,其生理、病理情况下对心血管系统的影响及在心血管疾病诊疗中的作用。

    Abstract:

    For the past few years, a unique type of adipose tissue, surrounding all of our cardiovascular system but cerebrovascular, known as perivascular adipose tissue (PVAT), has been seen as a new kind of adipose tissue different from the classic visceral fat due to its unusual anatomic location and function. It exerts a bidirectional effect on the cardiovascular system through the release of vasoconstrictive/relaxant adipokine in a paracrine / endocrine manner、the induction of inflammation and the change of its phenotype, including the protectional role under its physiological state and the deleterious influence under its pathological state. It also shows a potential role in the diagnosis and treatment of cardiovascular disease(CVD) as a new parameter and intervention. In this article, we will discuss its characteristics distinguished from classic adipose tissue and its effect on CVD under physiology/pathology conditions, also, its application in CVD diagnosis and treatment.

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  • 收稿日期:2022-12-01
  • 最后修改日期:2023-03-03
  • 录用日期:2023-05-10
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