OBJECTIVE:To study the precise timing of labor induction in GDM women with term premature rupture of membranes and its influence on maternal and child outcomes.METHODS:A retrospective analysis was performed on 585 pregnancies with premature rupture of membranes at term without other comorbidity and complications except GDM in Nanjing Maternal and Child Health Hospital from June 2017 to July 2021, which were divided into three groups according to the time interval time (P-O) between preterm rupture of membranes and initiation of oxytocin induction:group A (2~6h),group B (6~9h),group C (9~12h).The general clinical data, maternal and neonatal primary outcomes of the cases in the three groups were statistically analyzed.RESULTS:①The time from premature rupture of membranes to delivery (P-D) increased with the delay of induction of labor initiation (P-O)(P trend<0.05),with the shortest P-D time in group A(P <0.05);②The incidence of cesarean delivery, fever,chorioamnionitis , and intrauterine distress increased with the prolongation of P-O(P trend<0.05),of which the incidence was the lowest in group A(P <0.05);no statistical difference was found in the incidence of uterine contraction weakness, postpartum hemorrhage, and puerperal disease in the three groups;③the incidence of cesarean delivery due to uterine contraction weakness increased with the delay of P-O in the three groups(P trend<0.05);④the incidence of neonatal sepsis and neonatal intracranial hemorrhage in group A was significantly lower than that in group C(P trend<0.05),incidence were significantly lower than those in group C(P<0.05).CONCLUSION:In pregnant women with GDM and PROM at term, to exclude other complications and contraindications to vaginal delivery, the choice of oxytocin induction of labor with in 2~6h can both reduce the use of clinical antimicrobials and significantly reduce the incidence of adverse maternal and pediatric outcomes.