肿瘤细菌疗法在肿瘤临床治疗中的进展及应用
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江苏省南京市江宁区中国药科大学生物药物学院

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Advances and applications of bacteriotherapy in the clinical treatment of tumors
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School of Biopharmacy, China Pharmaceutical University, Nanjing, China

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    摘要:

    由于肿瘤及其微环境的复杂性,传统的癌症疗法存在严重局限,例如药物响应性差、毒副作用大、药物难以到达肿瘤深部、肿瘤易复发等。近年来,细菌介导的癌症免疫疗法以其独特的优势正引起人们的关注。该类细菌优先在肿瘤的缺氧区定植,通过重塑肿瘤免疫微环境、激活抗肿瘤免疫等多种机制杀伤肿瘤细胞。在此基础上,通过遗传工程技术构建重组抗肿瘤菌株,靶向肿瘤并在肿瘤核心区分泌治疗性蛋白或核酸药物,或与其他抗癌疗法联用,正有望成为种新的癌症治疗策略。本文围绕已开展临床实验的抗肿瘤细菌,介绍不同抗肿瘤细菌的研究进展及其临床应用现状,为肿瘤的细菌免疫治疗提供新思路。

    Abstract:

    Due to the complexity of tumor microenvironment, traditional cancer therapies have serious limitations, such as poor drug responsiveness, toxic side effects, difficulty in reaching deeper tumors, and tumors prone to recurrence. In recent years, bacterial-mediated cancer immunotherapy is attracting attention with its unique advantages. These bacteria preferentially colonize the hypoxic zone of tumors and kill tumor cells through various mechanisms such as reshaping the tumor immune microenvironment and activating anti-tumor immunity. Based on this, genetic engineering techniques to construct recombinant antitumor strains that target tumors and secrete therapeutic proteins or nucleic acid drugs in the tumor core or in combination with other anticancer therapies are promising as a new cancer treatment strategy. This paper introduces the research progress of different antitumor bacteria and their clinical application status, and provides new ideas for bacterial immunotherapy of tumors.

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  • 收稿日期:2022-12-31
  • 最后修改日期:2023-02-06
  • 录用日期:2023-05-11
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