奥密克戎变异株BF.7及BA.5.2感染新生儿的临床特征
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1.南京医科大学附属儿童医院;2.江苏省疾病预防控制中心

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Clinical characteristics of neonates infected with Omicron variants BF.7 and BA.5.2
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1.Children'2.'3.s Hospital of Nanjing Medical University

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    摘要:

    目的:探讨新型冠状病毒(新冠病毒)奥密克戎变异株BF.7及BA.5.2感染新生儿的临床特点,并且对感染不同亚型病毒株的新生儿临床特征进行比较。方法:选取2022年12月收治的疑似新冠病毒感染的新生儿,进行病毒核酸检测及分型,分析核酸阳性患儿的临床特点、实验室检查及转归,比较新生儿感染不同亚型病毒株的临床特征的差异。结果:新冠病毒核酸检测阳性新生儿43例,无症状感染2例,轻型37例,重型4例。轻型病例均表现为上呼吸道感染症状,其中3例伴有消化道症状;重型病例中3例表现为呼吸道症状,1例表现为消化道症状。症状性感染新生儿住院时间5.0(4.0,7.0)天,所有病例均治愈出院,大多数新生儿出院后随访无异常临床表现。对病毒载量较高的33例样本行全基因测序显示14例为奥密克戎变异株BF.7亚型,19例为BA.5.2亚型;BA.5.2病例中,2例为重型,17例为轻型,4例存在消化道症状,而BF.7组中,2例为无症状,12例为轻型,无病例表现为消化道症状;两组患儿在发病年龄、住院时间、发热、咳嗽、惊厥的发生率、实验室检查方面,差异无统计学意义(P>0.05)。结论:新生儿感染新冠病毒奥密克戎变异株后,临床以轻症、呼吸道症状为主,少数表现为消化道症状;感染BA.5.2亚型后,部分患儿出现消化道症状,少数患儿出现重型临床表现,奥密克戎变异株BA.5.2引起消化道症状、重症的发生率是否比BF.7更高需要进一步大样本的研究。

    Abstract:

    Objective: To explore the clinical characteristics of newborns infected with SARS‐CoV‐2 Omicron Subvariants BF.7 and BA. 5.2, and to compare the clinical characteristics of newborns infected with different subtypes of coronavirus strains. Methods: The newborns suspected of SARS‐CoV‐2 infection admitted in December 2022 were selected for viral nucleic acid detection and typing. The clinical characteristics, laboratory examination and prognosis of the newborns with nucleic acid positive were analyzed. The clinical characteristics of different subtype virus strains in newborns were compared. Results: There were 43 newborns with positive SARS‐CoV‐2 nucleic acid test, 2 asymptomatic infections, 37 mild infections and 4 severe infections. The mild cases all showed symptoms of upper respiratory tract infection, of which 3 cases were accompanied by gastrointestinal symptoms; Three severe case showed respiratory symptoms, and the other one showed gastrointestinal symptoms. The hospital stay of newborns with symptomatic infection was 5.0 (4.0, 7.0) days. All cases were cured and discharged. Most newborns were followed up without abnormal clinical manifestations after discharge. The whole gene sequencing of 33 samples with high viral load showed that 14 cases were Omicron BF.7 subtype and 19 cases were BA.5.2 subtype. In BA. 5.2 cases, 2 cases were severe, 17 cases were mild, and 4 cases had gastrointestinal symptoms, while in BF. 7 group, 2 cases were asymptomatic, 12 cases were mild, and no cases showed gastrointestinal symptoms. There was no significant difference between the two groups in terms of age of onset, hospital stay, incidence of fever, cough, convulsion, and laboratory examination (P>0.05). Conclusions: Neonates infected with SARS‐CoV‐2 Omicron variant are mainly characterized by mild symptoms and respiratory symptoms, and a few of them are characterized by gastrointestinal symptoms. After infection with BA.5.2 subtype, some children have gastrointestinal symptoms, and a few children have severe clinical symptoms. Whether the incidence of gastrointestinal symptoms and severe diseases caused by Omicron variant BA. 5.2 is higher than that caused by BF. 7 requires further large sample study.

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  • 收稿日期:2023-02-06
  • 最后修改日期:2023-03-19
  • 录用日期:2023-05-23
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